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HOLOPROSENCEPHALY 2 (disorder)

Known as: HOLOPROSENCEPHALY 2, HPE2, Holoprosencephaly Type 2 
A rare disorder characterized by the partial separation of the cerebral hemispheres. It is associated with mutations in the SIX3 gene.
National Institutes of Health

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Highly Cited
2002
Highly Cited
2002
Mice heterozygous for the Otx2 mutation display a craniofacial malformation, known as otocephaly or agnathia-holoprosencephaly… Expand
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2001
2001
Hypericum perforatum extracts (HPE) inhibit ethanol intake in rats. Hypericin and hyperforin have been proposed as major active… Expand
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Highly Cited
2000
Highly Cited
2000
Holoprosencephaly (HPE) is a severe brain malformation which results from incomplete cleavage of the forebrain during early… Expand
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Highly Cited
1999
Highly Cited
1999
Holoprosencephaly (HPE) is a common, severe malformation of the brain that involves separation of the central nervous system into… Expand
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Highly Cited
1999
Highly Cited
1999
The Drosophila gene sine oculis (so), a nuclear homeoprotein that is required for eye development, has several homologues in… Expand
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Highly Cited
1996
Highly Cited
1996
Holoprosencephaly (HPE) is a common developmental defect involving the brain and face in humans. Cytogenetic deletions in… Expand
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Highly Cited
1995
Highly Cited
1995
The Drosophila sine oculis homeobox-containing gene is known to play an essential role in controlling the initial events of… Expand
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Highly Cited
1994
Highly Cited
1994
Holoprosencephaly (HPE) is a common malformation of the developing forebrain and midface characterized by incomplete penetrance… Expand
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1991
1991
The rare syndrome of the agnathia with microstomia, aglossia, synotia (the external ears approaching one another in the midline… Expand
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Highly Cited
1983
Highly Cited
1983
Two stillborn sisters had characteristics of both agnathia and holoprosencephaly. Familial occurrence implies that agnathia… Expand
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