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HLA-DQB1 gene

Known as: IDDM1, Major Histocompatibility Complex, Class II, DQ Beta 1 Gene, CELIAC1 
This gene is involved in the mediation of antigen presentation.
National Institutes of Health

Related topics

Related topics

12 relations
Antigen PresentationHLA-DOA geneHLA-DOB geneHLA-DPB2 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Iddm1 and Iddm2 homozygous WOK.4BB rats develop lymphopenia, but no hyperglycemia like the BB/OK rats.
BB rats develop type 1 diabetes and WOKW rats facets of the metabolic syndrome. Both strains are common the RT1 (u) haplotype of… 
2005
2005
A Second Component of HLA‐Linked Susceptibility to Type 1 Diabetes Maps to Class I Region
Abstract:  Type 1 diabetes is a polygenic disease with a major susceptibility locus, IDDM1, located in the human leukocyte… 
2003
2003
Alleles of diabetes-resistant BN rats contribute to insulin-dependent type 1 diabetes mellitus.
Highly Cited
2000
Highly Cited
2000
Evaluation of fine mapping strategies for a multifactorial disease locus: systematic linkage and association analysis of IDDM1 in the HLA region on chromosome 6p21.
The positional cloning of multifactorial disease genes is a major challenge in human genetics. We have therefore empirically… 
2000
2000
Assessment of the non‐HLA‐DR‐DQ contribution to IDDM1 in British Caucasian families: analysis of LMP7 polymorphisms
SUMMARY 
1999
1999
A diabetogenic gene prevents T cells from receiving costimulatory signals.
T cell fate following antigen encounter is determined by several intracellular signals generated by the interaction of the T cell… 
1998
1998
Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat.
By several crossing studies it has been demonstrated that the MHC class-II genes of the RT1u haplotype, Iddm1, and the… 
1998
1998
Investigation of linkage of chromosome 8 to type 1 diabetes: multipoint analysis and exclusion mapping of human chromosome 8 in 593 affected sib-pair families from the U.K. and U.S.
Type 1 diabetes is a common multifactorial disease that is strongly clustered in families: the sibling risk-to-population… 
Review
1998
Review
1998
Advances and controversies in etiopathogenesis of type 1 (insulin-dependent) diabetes mellitus.
UNLABELLED The present state of knowledge and controversies about the etiopathogenesis of tyep 1 diabetes can be summarized as… 
1998
1998
Association of distal chromosome 2q with IDDM in Japanese subjects
Summary An insulin-dependent diabetes mellitus (IDDM)-susceptibility gene (IDDM13) has recently been mapped to a region of distal… 
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