HIF1A wt Allele

Known as: HIF1, HIF-1alpha, PASD8 
Human HIF1A wild-type allele is located within 14q21-q24 and is approximately 53 kb in length. This allele, which encodes hypoxia-inducible factor 1… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2018
020406019982018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
The hypoxic response is an ancient stress response triggered by low ambient oxygen (O2) (ref. 1) and controlled by… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2006
Highly Cited
2006
BACKGROUND Inadequate oxygen (hypoxia) triggers a multifaceted cellular response that has important roles in normal physiology… (More)
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Hypoxia promotes genetic instability by undefined mechanisms. The transcription factor HIF-1alpha is crucial for the cellular… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
BACKGROUND Hypoxia-inducible factor 1 (HIF-1), a heterodimer comprising the oxygen-regulated subunit, HIF-1alpha, and HIF-1beta… (More)
Is this relevant?
Highly Cited
2003
Highly Cited
2003
BACKGROUND Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that plays an important role in tumor growth and… (More)
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Understanding molecular mechanisms regulating angiogenesis may lead to novel therapies for ischemic disorders. Hypoxia-inducible… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor induced by hypoxia. Under normoxic conditions, site… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Breakdown or absence of vascular oxygen delivery is a hallmark of many common human diseases, including cancer, myocardial… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
The switch to an angiogenic phenotype is a fundamental determinant of neoplastic growth and tumor progression. We demonstrate… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Neovascularization and increased glycolysis, two universal characteristics of solid tumors, represent adaptations to a hypoxic… (More)
  • figure 1
  • table 2
  • table 1
  • table 3
  • figure 2
Is this relevant?