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HIF1A wt Allele

Known as: HIF1, HIF-1alpha, PASD8 
Human HIF1A wild-type allele is located within 14q21-q24 and is approximately 53 kb in length. This allele, which encodes hypoxia-inducible factor 1… Expand
National Institutes of Health

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Highly Cited
2008
Highly Cited
2008
The hypoxic response is an ancient stress response triggered by low ambient oxygen (O2) (ref. 1) and controlled by hypoxia… Expand
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Inadequate oxygen (hypoxia) triggers a multifaceted cellular response that has important roles in normal physiology… Expand
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Highly Cited
2005
Highly Cited
2005
Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding angiogenic growth factors, which are secreted by… Expand
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Highly Cited
2003
Highly Cited
2003
Hypoxia-inducible factor (HIF), a transcriptional complex conserved from Caenorhabditis elegans to vertebrates, plays a pivotal… Expand
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Highly Cited
2002
Highly Cited
2002
The hypoxia-inducible factors (HIFs) 1alpha and 2alpha are key mammalian transcription factors that exhibit dramatic increases in… Expand
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Highly Cited
2001
Highly Cited
2001
Adaptation to hypoxia is regulated by hypoxia-inducible factor 1 (HIF-1), a heterodimeric transcription factor consisting of an… Expand
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Review
2000
Review
2000
All organisms can sense O(2) concentration and respond to hypoxia with adaptive changes in gene expression. The large body size… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND When the myocardium is deprived of blood, a process of ischemia, infarction, and myocardial remodeling is initiated… Expand
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Highly Cited
1999
Highly Cited
1999
Neovascularization and increased glycolysis, two universal characteristics of solid tumors, represent adaptations to a hypoxic… Expand
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Highly Cited
1999
Highly Cited
1999
Hypoxia-inducible factor-1 (HIF-1) controls the expression of a number of genes such as vascular endothelial growth factor and… Expand
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