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HHV8 ORF59 Gene

Known as: Human Herpesvirus-8 ORF59 Gene, ORF59, Human Herpesvirus-8 Open Reading Frame 59 Gene 
HHV8 ORF59, which encodes DNA polymerase processivity factor protein, plays a role in viral DNA replication.
National Institutes of Health

Related topics

Related topics

5 relations
Lytic PhaseORF59 protein, Human herpesvirus 8Transcriptional ActivationVirus Physiological Phenomena
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Papers overview

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Highly Cited
2009
Highly Cited
2009
Genome-wide identification of binding sites for Kaposi's sarcoma-associated herpesvirus lytic switch protein, RTA.
Kaposi's sarcoma-associated herpesvirus (KSHV) replication and transcription activator (RTA) encoded by ORF50 is a lytic switch… Expand
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Highly Cited
2008
Highly Cited
2008
Genetic disruption of KSHV major latent nuclear antigen LANA enhances viral lytic transcriptional program.
Following primary infection, KSHV establishes a lifelong persistent latent infection in the host. The mechanism of KSHV latency… Expand
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Highly Cited
2007
Highly Cited
2007
In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi's sarcoma.
Transfection of a Kaposi's sarcoma (KS) herpesvirus (KSHV) Bacterial Artificial Chromosome (KSHVBac36) into mouse bone marrow… Expand
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Highly Cited
2006
Highly Cited
2006
Structural and Functional Analyses of Kaposi Sarcoma-associated Herpesvirus ORF57 Nuclear Localization Signals in Living Cells*
Kaposi sarcoma-associated herpesvirus (KSHV) ORF57 is a multifunctional, nuclear protein involved in post-transcriptional… Expand
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Highly Cited
2006
Highly Cited
2006
Targeted Disruption of Kaposi's Sarcoma-Associated Herpesvirus ORF57 in the Viral Genome Is Detrimental for the Expression of ORF59, K8α, and K8.1 and the Production of Infectious Virus
ABSTRACT Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 regulates viral gene expression at the posttranscriptional level… Expand
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Highly Cited
2001
Highly Cited
2001
Origin-Independent Assembly of Kaposi's Sarcoma-Associated Herpesvirus DNA Replication Compartments in Transient Cotransfection Assays and Association with the ORF-K8 Protein and Cellular PML
ABSTRACT Six predicted Kaposi's sarcoma virus herpesvirus (KSHV) proteins have homology with other well-characterized herpesvirus… Expand
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Highly Cited
2001
Highly Cited
2001
HHV-8 infection status of AIDS-unrelated and AIDS-associated multicentric Castleman's disease.
Multicentric Castleman's disease (MCD) is a clinicopathologically defined entity characterized by systemic lymphadenopathy with… Expand
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Highly Cited
2001
Highly Cited
2001
Major histocompatibility complex class I molecules are down-regulated at the cell surface by the K5 protein encoded by Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8.
The expression of major histocompatibility complex class I (MHC-I) molecules at the cell surface was down-regulated in BC-3 cells… Expand
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2001
2001
Effective Human Herpesvirus 8 Infection of Human Umbilical Vein Endothelial Cells by Cell-Mediated Transmission
ABSTRACT Cell-free transmission of human herpesvirus 8 (HHV-8) to human cells in vitro has been reported to be difficult, if not… Expand
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Highly Cited
2000
Highly Cited
2000
Expression and localization of human herpesvirus 8-encoded proteins in primary effusion lymphoma, Kaposi's sarcoma, and multicentric Castleman's disease.
To investigate the expression of human herpesvirus 8 (HHV8)-encoded proteins in the cells of primary effusion lymphoma (PEL… Expand
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