HFE2 gene

Known as: Hemochromatosis Type 2 (Juvenile) Gene, haemojuvelin, repulsive guidance molecule c 
This gene plays a role in iron metabolism.
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Mutations in HFE lead to hereditary hemochromatosis (HH) because of inappropriately high iron uptake from the diet resulting from… (More)
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Highly Cited
2010
Highly Cited
2010
Iron overload in humans is associated with a variety of genetic and acquired conditions. Of these, HFE hemochromatosis (HFE-HC… (More)
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Highly Cited
2009
Highly Cited
2009
Juvenile hemochromatosis is an iron-overload disorder caused by mutations in the genes encoding the major iron regulatory hormone… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND The circulating hormone hepcidin plays a central role in iron homeostasis. Our goal was to establish an ex vivo iron… (More)
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Highly Cited
2008
Highly Cited
2008
The liver peptide hepcidin regulates iron absorption and recycling. Hemojuvelin (HJV) has a key role in hepcidin regulation, and… (More)
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Highly Cited
2008
Highly Cited
2008
The precise regulation of the iron-regulatory hormone hepcidin is essential to maintain body iron homeostasis: Hepcidin… (More)
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Highly Cited
2007
Highly Cited
2007
The peptide hormone hepcidin is the principal regulator of systemic iron homeostasis. We examined the pathway by which iron… (More)
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Highly Cited
2006
Highly Cited
2006
Hepcidin is a key regulator of systemic iron homeostasis. Hepcidin deficiency induces iron overload, whereas hepcidin excess… (More)
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Highly Cited
2006
Highly Cited
2006
Recently, it has been suggested that hepcidin, a peptide involved in iron homeostasis, is regulated by bone morphogenetic… (More)
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Review
2005
Review
2005
The term "non-HFE hemochromatosis" (non-HFE HC) refers to several phenotypically similar but genetically distinct forms of… (More)
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