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Hepcidin is a key hormone that is involved in the control of iron homeostasis in the body. Physiologically, hepcidin is… Expand Hereditary hemochromatosis is caused by mutations in the hereditary hemochromatosis protein (HFE), transferrin-receptor 2 (TfR2… Expand The mechanisms that allow the body to sense iron levels in order to maintain iron homeostasis are unknown. Patients with the most… Expand Lack of functional hereditary hemochromatosis protein, HFE, causes iron overload predominantly in hepatocytes, the major site of… Expand HFE and transferrin receptor 2 (TFR2) are membrane proteins integral to mammalian iron homeostasis and associated with human… Expand Iron is essential for life in almost all organisms and, in mammals, is absorbed through the villus cells of the duodenum. Using a… Expand The transferrin receptor (TfR) interacts with two proteins important for iron metabolism, transferrin (Tf) and HFE, the protein… Expand The enterocyte is a highly specialized cell of the duodenal epithelium that coordinates iron uptake and transport into the body… Expand HFE is the protein product of the gene mutated in the autosomal recessive disease hereditary hemochromatosis (Feder, J. N… Expand A transfectant HeLa cell clone expressing HFE under the control of a tetracycline‐repressible promoter was generated. HFE… Expand