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HFE protein, human

Known as: HJV protein, human, MHC Class I-Like Protein HFE, HLA H antigen, human 
Hereditary hemochromatosis protein (348 aa, ~40 kDa) is encoded by the human HFE gene. This protein plays a role in the regulation of transport of… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Hepcidin is a key hormone that is involved in the control of iron homeostasis in the body. Physiologically, hepcidin is… Expand
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Highly Cited
2010
Highly Cited
2010
Hereditary hemochromatosis is caused by mutations in the hereditary hemochromatosis protein (HFE), transferrin-receptor 2 (TfR2… Expand
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Highly Cited
2009
Highly Cited
2009
The mechanisms that allow the body to sense iron levels in order to maintain iron homeostasis are unknown. Patients with the most… Expand
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Highly Cited
2008
Highly Cited
2008
Lack of functional hereditary hemochromatosis protein, HFE, causes iron overload predominantly in hepatocytes, the major site of… Expand
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Highly Cited
2006
Highly Cited
2006
HFE and transferrin receptor 2 (TFR2) are membrane proteins integral to mammalian iron homeostasis and associated with human… Expand
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2005
2005
Hereditary hemochromatosis (HH) is an autosomal recessive disease that leads to parenchymal iron accumulation. The most common… Expand
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2004
2004
Iron is essential for life in almost all organisms and, in mammals, is absorbed through the villus cells of the duodenum. Using a… Expand
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2003
2003
The mechanisms by which the hereditary hemochromatosis protein, HFE, decreases transferrin-mediated iron uptake were examined… Expand
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Highly Cited
2000
Highly Cited
2000
The transferrin receptor (TfR) interacts with two proteins important for iron metabolism, transferrin (Tf) and HFE, the protein… Expand
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Highly Cited
1999
Highly Cited
1999
HFE is the protein product of the gene mutated in the autosomal recessive disease hereditary hemochromatosis (Feder, J. N… Expand
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