Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

HFE protein, human

Known as: HJV protein, human, MHC Class I-Like Protein HFE, HLA H antigen, human 
Hereditary hemochromatosis protein (348 aa, ~40 kDa) is encoded by the human HFE gene. This protein plays a role in the regulation of transport of… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Hepcidin is a key hormone that is involved in the control of iron homeostasis in the body. Physiologically, hepcidin is… Expand
  • figure 1
  • figure 2
  • table 1
  • table 2
Highly Cited
2010
Highly Cited
2010
Hereditary hemochromatosis is caused by mutations in the hereditary hemochromatosis protein (HFE), transferrin-receptor 2 (TfR2… Expand
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Highly Cited
2009
Highly Cited
2009
The mechanisms that allow the body to sense iron levels in order to maintain iron homeostasis are unknown. Patients with the most… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 5
  • figure 6
Highly Cited
2008
Highly Cited
2008
Lack of functional hereditary hemochromatosis protein, HFE, causes iron overload predominantly in hepatocytes, the major site of… Expand
  • table 1
  • figure 1
  • figure 2
  • figure 4
  • figure 3
Highly Cited
2006
Highly Cited
2006
HFE and transferrin receptor 2 (TFR2) are membrane proteins integral to mammalian iron homeostasis and associated with human… Expand
  • figure 1
  • figure 2
  • figure 3
2004
2004
Iron is essential for life in almost all organisms and, in mammals, is absorbed through the villus cells of the duodenum. Using a… Expand
  • table I
  • figure 1
  • figure 2
  • figure 3
  • table II
Highly Cited
2000
Highly Cited
2000
The transferrin receptor (TfR) interacts with two proteins important for iron metabolism, transferrin (Tf) and HFE, the protein… Expand
  • figure 1
  • table I
  • figure 2
  • figure 3
Review
2000
Review
2000
The enterocyte is a highly specialized cell of the duodenal epithelium that coordinates iron uptake and transport into the body… Expand
  • figure 1
  • figure 2
  • figure 3
Highly Cited
1999
Highly Cited
1999
HFE is the protein product of the gene mutated in the autosomal recessive disease hereditary hemochromatosis (Feder, J. N… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Highly Cited
1999
Highly Cited
1999
A transfectant HeLa cell clone expressing HFE under the control of a tetracycline‐repressible promoter was generated. HFE… Expand