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Introduction Notch signalling, an evolutionarily conserved mechanism of cellular differentiation and tissue remodelling, is… Expand Abstract NOTCH regulates stem cells during normal development and stemlike cells in cancer, but the roles of NOTCH in the lethal… Expand UNLABELLED
Next-generation sequencing was used to identify Notch mutations in a large collection of diverse solid tumors. NOTCH1… Expand The retina of fish and amphibian contains genuine neural stem cells located at the most peripheral edge of the ciliary marginal… Expand Purpose: We aimed to assess the biologic activity of PF-03084014 in breast xenograft models. The biomarkers for mechanism and… Expand Notch signaling pathway maintains stem cells through transcriptional activation of HES/HEY family members to repress tissue… Expand The 5T4 oncofoetal antigen is a cell surface glycoprotein that is transiently expressed during mouse ES cell differentiation and… Expand Human embryonic stem (ES) cell lines that have the ability to self‐renew and differentiate into specific cell types have been… Expand Activation of Notch signaling pathway leads to nuclear translocation of Notch intracellular domain (NIC), and transcriptional… Expand MMTV induces the mouse mammary tumor through the dysregulation of Notch, Wnt, or Fgf signaling pathway. Activation of Notch… Expand