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HER2-targeted Liposomal Doxorubicin Hydrochloride MM-302

Known as: MM-302 
An antibody-targeted lipidic nano-carrier containing the antineoplastic anthracycline antibiotic doxorubicin encapsulated within liposomes, and… Expand
National Institutes of Health

Papers overview

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2018
2018
An issue of concern is that no current HER2-targeted therapeutic agent is effective against Trastuzumab (Tmab)-resistant gastric… Expand
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2018
2018
BackgroundThis phase 1 dose-escalation trial studied MM-302, a novel HER2-targeted PEGylated antibody–liposomal doxorubicin… Expand
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Highly Cited
2017
Highly Cited
2017
Purpose: Therapeutic nanoparticles are designed to deliver their drug payloads through enhanced permeability and retention (EPR… Expand
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Highly Cited
2016
Highly Cited
2016
BackgroundHuman epidermal growth factor receptor 2 (HER2)-positive breast cancer is a particularly aggressive form of the disease… Expand
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Highly Cited
2016
Highly Cited
2016
Trastuzumab is the standard of care for HER2-positive breast cancer patients, markedly improving disease-free and overall… Expand
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2015
2015
Given the bulky nature of nanotherapeutics relative to small molecules, it is hypothesized that effective tumor delivery and… Expand
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2015
2015
Effective drug delivery to tumors is a barrier to treatment with nanomedicines. Non-invasively tracking liposome biodistribution… Expand
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2015
2015
Background: MM-302 is an antibody drug conjugated HER2-targeted liposomal doxorubicin in development by Merrimack Pharmaceuticals… Expand
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2013
2013
The studies described herein assess the potential of combining platinum-based chemotherapy with high-linear energy transfer (LET… Expand
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2012
2012
Background: Anthracyclines have been an effective backbone of breast cancer therapies for decades. However, cardiotoxicity issues… Expand
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