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HDAC8 gene

Known as: Histone Deacetylase 8 Gene, HISTONE DEACETYLASE 8, HDAC8 
This gene is involved in the modification of histone proteins.
National Institutes of Health

Related topics

Related topics

11 relations
Cell Cycle ProgressionDevelopmental processHDAC1 geneHDAC1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
A combined pharmacophore modeling, 3D QSAR, virtual screening, molecular docking, and ADME studies to identify potential HDAC8 inhibitors
The World Cancer Report 2014 shows that cancer is a leading cause of death globally, and cancer related death is likely to go up… 
2016
2016
Design and evaluation of novel histone deacetylase 8 inhibitors
Chapter One gives an introduction to the biological importance of HDACs and in particular of HDAC8. It discusses the structural… 
2015
2015
Structure-dynamics-function relation of metalloproteins : coupling magnetic resonance spectroscopy and simulation
Dynamics of proteins are increasingly recognised as key features as they can contribute to the function of the protein… 
2014
2014
Effect of two series of isoindolines over HDAC8 activity and expression
This work describes the effect of two series of isoindolines 1(a–g) and 2(a–g) on histone deacetylase 8 (HDAC8) activity by… 
2014
2014
Reply to "Letter to the editor: 'KDAC and the regulation of nonnuclear smooth muscle protein acetylation'".
reply: We appreciate the interest expressed by Taggart and colleagues ([9][1]) in our article ([6][2]) for American Journal of… 
2013
2013
SOX 4 is a direct target gene of FRA-2 and induces expression of HDAC 8 in adult T-cell leukemia / lymphoma
• SOX4 is consistently expressed in ATL, is involved in ATL cell growth, and induces genes such as GCRK, NAP1, and HDAC8 in ATL… 
2010
2010
Discovery of a novel histone deacetylase 8 inhibitor by virtual screening
In order to develop potent histone deacetylase inhibitors, a virtual screening approach was performed to discover novel lead… 
2009
2009
Structural Studies of Two Related Metallohydrolases: Human Histone Deacetylase 8 and Malarial Arginase
Metal-dependent histone deacetylases (HDACs) catalyze the deacetylation of lysine residues in histones and other proteins in… 
2006
2006
Effects of trichostatin A on HDAC8 expression, proliferation and cell cycle of Molt-4 cells
The effects of Trichostatin A (TSA) on histone deacetylase 8 (HDAC8) expression, proliferation and cell cycle arrest in T… 
2006
2006
Human histone deacetylase 8: Metal dependence and catalytic mechanism.
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