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Guanylyl Imidodiphosphate

Known as: Gpp(NH)p, Guanosine 5'-(Beta,Gamma-Imido)Triphosphate, Guanyl 5' Imidodiphosphate 
A non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly… 
National Institutes of Health

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In Bloodagonistsanalogs & derivativesantagonists & inhibitors

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technetium Tc 99m 5'-guanylylimidodiphosphate

Papers overview

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1987
1987
The hepatic glucagon receptor: a comparative study of the regulatory and structural properties.
Guanine nucleotide and Mg2+ ion regulation of [125I-Tyr10]monoiodoglucagon ([125I]MIG) binding to liver plasma membranes from… 
Highly Cited
1986
Highly Cited
1986
Stimulation of luteinizing hormone (LH) release and phospholipid breakdown by guanosine triphosphate in permeabilized pituitary gonadotropes: antagonist action suggests association of a G protein and…
The stimulation of gonadotropin release from pituitary cell cultures by GnRH has been linked to inositol phospholipid breakdown… 
1985
1985
Reversible Inhibition of Adenylate Cyclase Activity in the Ischemic Myocardium
Adenylate cyclase (AC) function was studied in homogenate and paniculate preparations of ischemic rat heart obtained from three… 
1984
1984
Muscarinic cholinergic receptors in peripheral lung tissue of normal subjects and of patients with chronic obstructive lung disease.
Muscarinic cholinergic receptors have been identified and characterized by radioligand binding studies in human peripheral lung… 
Highly Cited
1980
Highly Cited
1980
Mechanism of desensitization of adenylate cyclase in lutropin. GTP-dependent uncoupling of the receptor.
Lutropin-sensitive adenylate cyclase ((EC 4.6.1.1) ATP pyrophosphate-lyase (cyclizing)) in purified rat ovarian plasma membranes… 
1979
1979
Coupling of glucagon receptor to adenylyl cyclase. Requirement of a receptor-related guanyl nucleotide binding site for coupling of receptor to the enzyme.
Effects of glucagon and guanyl nucleotides on the rat liver plasma membrane adenylyl cyclase were studied. It was established… 
1978
1978
Formation of a ternary complex: actin, 5'-adenylyl imidodiphosphate, and the subfragments of myosin.
The formation of the ternary complex composed of actin, 5'-adenylyl imidodiphosphate [AMP-P(NH)P], and myosin subfragment 1 (S-1… 
1977
1977
Catecholamine-sensitive adenylate cyclase of caudate nucleus and cerebral cortex. Effects of guanine nucleotides.
1. GTP and GMP-P(NH)P (guanyl-5'-yl imidodiphosphate) were observed to increase the stimulation of neural adenylate cyclase by… 
Highly Cited
1976
Highly Cited
1976
Light-induced exchange of nucleotides into coupling factor 1 in spinach chloroplast thylakoids.
The method of centrifugation of chloroplast thylakoids through silicone fluid, previously used to estimate the uptake of solutes… 
1975
1975
Activation of adenylate cyclase by phosphoramidate and phosphonate analogs of GTP: possible role of covalent enzyme-substrate intermediates in the mechanism of hormonal activation.
Incubation of rat fat pad membranes with 5-guanylyliminodiphosphonate [Gpp-(NH)p] and 5-guanylylmethylenediphosphonate [Gpp(CH2)p…