Guanabenz

Known as: 2,6-Dichlorobenzylideneaminoguanidine, Guanabenzum, Guanabenzo 
An alpha-2 selective adrenergic agonist used as an antihypertensive agent.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1976-2017
0246819762017

Papers overview

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2014
2014
Approximately 20% of familial amyotrophic lateral sclerosis (FALS) cases are caused by mutant superoxide dismutase type 1 (mtSOD1… (More)
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2014
2014
Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative disease characterized by the loss of motor… (More)
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2008
2008
BACKGROUND Prion-based diseases are incurable transmissible neurodegenerative disorders affecting animals and humans… (More)
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Highly Cited
2000
Highly Cited
2000
The alpha-2 adrenergic receptor agonists, clonidine, lofexidine and guanabenz, blocked stress- but not cocaine-induced… (More)
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2000
2000
Guanabenz, a metabolism-based irreversible inactivator of neuronal nitric-oxide synthase (nNOS) in vitro, causes the loss of… (More)
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2000
2000
The cardiovascular and sympatholytic effects of combination therapy with guanabenz were examined in 26 patients (48 ± 13 years… (More)
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1998
1998
Guanabenz (Wytensin) was shown to inactivate nitric oxide synthase (NOS) activity in vitro and in vivo. In in vitro studies with… (More)
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1987
1987
Guanabenz (2,6-dichlorobenzylidene amino guanidine acetate), an alpha 2-agonist, possesses antiinflammatory activity. Since… (More)
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1986
1986
Guanabenz is acutely natriuretic and diuretic in saline expanded animals. In man, guanabenz has not resulted in sodium retention… (More)
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1976
1976
Prior studies demonstrated that guanabenz reduces systemic blood pressure by inhibiting central sympathetic outflow as well as by… (More)
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