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Growth Factor Inhibition

Growth Factor Inhibition involves interference with, or restraint of, the activities of extracellular signaling molecules (ligands) involved in the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1986-2017
024619862017

Related topics

Related topics

7 relations
AE-941Protein Sprouty Homolog 4SPRY4 geneSuramin
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Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
Growth Factor Inhibition
bevacizumab
Suramin
ranibizumab
Suramin Sodium
Protein Sprouty Homolog 4

Papers overview

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2014
2014
Neuronal cell death in the inner retina and the influence of vascular endothelial growth factor inhibition in a diabetic rat model.
To inhibit vascular changes in diabetic retinopathy, inhibiting vascular endothelial growth factor (VEGF) has become a mainstay… (More)
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Highly Cited
2013
Highly Cited
2013
Long-term outcomes of ranibizumab therapy for diabetic macular edema: the 36-month results from two phase III trials: RISE and RIDE.
PURPOSE To report 36-month outcomes of RIDE (NCT00473382) and RISE (NCT00473330), trials of ranibizumab in diabetic macular edema… (More)
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Highly Cited
2012
Highly Cited
2012
Ranibizumab for diabetic macular edema: results from 2 phase III randomized trials: RISE and RIDE.
PURPOSE To evaluate the efficacy and safety of intravitreal ranibizumab in diabetic macular edema (DME) patients. DESIGN Two… (More)
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2011
2011
Effect of vascular endothelial growth factor inhibition on endometrial implant development in a murine model of endometriosis.
The main factor involved in neovascularization of ectopic endometrial tissue in endometriosis is the vascular endothelial growth… (More)
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Highly Cited
2010
Highly Cited
2010
Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: implications for AMG 386, an angiopoietin-1/2-neutralizing peptibody.
AMG 386 is an investigational first-in-class peptide-Fc fusion protein (peptibody) that inhibits angiogenesis by preventing the… (More)
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Highly Cited
2008
Highly Cited
2008
Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: results from a large observational cohort study (BRiTE).
PURPOSE Bevacizumab provides a survival benefit in first- and second-line metastatic colorectal cancer (mCRC). In a large… (More)
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2008
2008
Hypoxia-inducible factor-1 target genes as indicators of tumor vessel response to vascular endothelial growth factor inhibition.
Antiangiogenic therapy improves survival in patients with advanced stage cancers. Currently, there are no reliable predictors or… (More)
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2007
2007
Early inhaled nitric oxide treatment decreases apoptosis of endothelial cells in neonatal rat lungs after vascular endothelial growth factor inhibition.
Vascular endothelial growth factor (VEGF) receptor blockade impairs lung growth and decreases nitric oxide (NO) production in… (More)
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Highly Cited
2002
Highly Cited
2002
Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery.
A mechanism that triggers neuronal apoptosis has been characterized. We report that the cell cycle-regulated protein kinase Cdc2… (More)
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Highly Cited
1999
Highly Cited
1999
Novel approach to specific growth factor inhibition in vivo: antagonism of platelet-derived growth factor in glomerulonephritis by aptamers.
Mesangial cell proliferation and matrix accumulation, driven by platelet-derived growth factor (PDGF), contribute to many… (More)
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