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Glyoxalase II Deficiency

Known as: HYDROXYACYL GLUTATHIONE HYDROLASE DEFICIENCY 
National Institutes of Health

Related topics

Related topics

3 relations
Autosomal dominant inheritance

Broader (2)

Elliptocytosis, HereditaryInborn Errors of Metabolism

Papers overview

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2015
2015
Modulating glyoxalase I metal selectivity by deletional mutagenesis: underlying structural factors contributing to nickel activation profiles.
Metabolically produced methylglyoxal is a cytotoxic compound that can lead to covalent modification of cellular DNA, RNA and… 
2011
2011
Identification of curcumin derivatives as human glyoxalase I inhibitors: A combination of biological evaluation, molecular docking, 3D-QSAR and molecular dynamics simulation studies.
2010
2010
Inhibition of Methylglyoxal-Mediated Protein Modification in Glyoxalase I Overexpressing Mouse Lenses
Objective. Here we tested the role of Glo I in the prevention of advanced glycation end product (AGE) formation in transgenic… 
2009
2009
Glyoxalase I activity and immunoreactivity in the aging human lens
Glyoxalase I (GLOI) is the first enzyme of the glyoxalase system that catalyzes the metabolism of reactive dicarbonyls, such as… 
2006
2006
Upregulation of Glyoxalase I fails to Normalize Methylglyoxal Levels: A Possible Mechanism for Biochemical Changes in Diabetic Mouse Lenses
Glyoxalase I is the first enzyme in a two-enzyme glyoxalase system that metabolizes physiological methylglyoxal (MGO). MGO reacts… 
2005
2005
Unique regulation of glyoxalase I activity during osmotic stress response in the fission yeast Schizosaccharomyces pombe: neither the mRNA nor the protein level of glyoxalase I increase under…
Glyoxalase I is a ubiquitous enzyme that catalyzes the conversion of methylglyoxal, a toxic 2-oxoaldehyde derived from glycolysis… 
1995
1995
Evidence for a (Triosephosphate Isomerase-like) "Catalytic Loop" near the Active Site of Glyoxalase I (*)
The conformational mobility of glyoxalase I (Glx I) during catalysis has been probed using stable analogs of the enediol… 
1986
1986
Population genetics of glyoxalase I (GLO) polymorphism in India.
Phenotype and gene frequency data are presented on the glyoxalase I (GLO) polymorphism in seven endogamous caste groups: Jat Sikh… 
1986
1986
Frequencies of glyoxalase I phenotypes as biological markers in chronic alcoholism.
1977
1977
Glyoxalase I polymorphism in South African Bantu-speaking Negroids
SummaryThe newly described genetic polymorphism of glyoxalase I (GLO) is studied in seven ethnically defined Negroid samples from… 
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