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Glycinamide Ribonucleotide Formyltransferase Inhibitor
Any substance that inhibits glycinamide ribonucleotide formyltransferase, the first folate dependent enzyme in de novo purine synthesis. Inhibition…
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National Institutes of Health
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2009
2009
Abstract #1684: Discovery of a glycinamide ribonucleotide formyltransferase inhibitor with solid tumor selectivity via its transport by the proton-coupled folate transporter
S. Desmoulin
,
Yiqiang Wang
,
+4 authors
L. Matherly
2009
Corpus ID: 80009697
The human proton-coupled folate transporter (hPCFT) is a folate-proton symporter that functions optimally at low pH. hPCFT could…
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1999
1999
Cellular pharmacology of MTA: a correlation of MTA-induced cellular toxicity and in vitro enzyme inhibition with its effect on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells…
Victor J. Chen
,
J. Bewley
,
+6 authors
J. Tonkinson
Seminars in Oncology
1999
Corpus ID: 31968197
The mechanism of action of an antifolate may be investigated using a variety of experimental methods. These include experiments…
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