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Glembatumumab
Known as:
Immunoglobulin G2, Anti-(Human Transmembrane Glycoprotein NMB (HGFIN) Extracellular Domain) Human Monoclonal CR011 Heavy Chain (133-215')-Disulfide with Human Monoclonal CR011 Kappa Light Chain, Dimer (221-221'':222-222'':225-225'':228- 228'')-Tetrakis
, Immunoglobulin, Anti-(Human Glycoprotein NMB Extracellular Domain) (Human Monoclonal CR011 Heavy Chain), Disulfide with Human Monoclonal CR011 Gamma-2 Kappa-Chain, Dimer
A human monoclonal antibody against transmembrane glycoprotein non-metastatic melanoma protein B (GPNMB). Glembatumumab binds to GPNMB on cancer…
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National Institutes of Health
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Related topics
Related topics
2 relations
Narrower (1)
CR011
antigen binding
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
A phase 2 study of glembatumumab vedotin, an antibody‐drug conjugate targeting glycoprotein NMB, in patients with advanced melanoma
P. Ott
,
A. Pavlick
,
+15 authors
O. Hamid
Cancer
2019
Corpus ID: 59339417
Glembatumumab vedotin is an antibody‐drug conjugate that produced preliminary clinical activity against advanced melanoma in a…
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Review
2016
Review
2016
Effects of antibody, drug and linker on the preclinical and clinical toxicities of antibody-drug conjugates
H. Donaghy
mAbs
2016
Corpus ID: 17278582
ABSTRACT Antibody-drug conjugates (ADCs) represent a new class of cancer therapeutics. Their design involves a tumor-specific…
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2016
2016
Identification of gamma-synuclein as a new PCBP1-interacting protein
Amanda Hunkele
,
Hamidah Sultan
,
Faith A. Ikalina
,
Alexander H. Liu
,
Pranjal Nahar‐Gohad
,
J. Ko
Neurological Research
2016
Corpus ID: 1728404
Objectives: PolyC binding protein 1 (PCBP1) is a transcriptional regulator of human mu-opioid receptor (hMOR) gene in the CNS and…
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Highly Cited
2015
Highly Cited
2015
EMERGE: A Randomized Phase II Study of the Antibody-Drug Conjugate Glembatumumab Vedotin in Advanced Glycoprotein NMB-Expressing Breast Cancer.
D. Yardley
,
R. Weaver
,
+17 authors
L. Vahdat
Journal of Clinical Oncology
2015
Corpus ID: 207037468
PURPOSE Glycoprotein NMB (gpNMB), a negative prognostic marker, is overexpressed in multiple tumor types. Glembatumumab vedotin…
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2014
2014
Initial testing (stage 1) of glembatumumab vedotin (CDX‐011) by the pediatric preclinical testing program
E. Kolb
,
R. Gorlick
,
+4 authors
Malcolm A. Smith
Pediatric Blood & Cancer
2014
Corpus ID: 13764517
Glembatumumab vedotin is an antibody‐auristatin conjugate that targets cells expressing the transmembrane glycoprotein NMB (GPNMB…
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Highly Cited
2010
Highly Cited
2010
Glembatumumab vedotin, a conjugate of an anti-glycoprotein non-metastatic melanoma protein B mAb and monomethyl auristatin E for the treatment of melanoma and breast cancer.
L. Naumovski
,
J. R. Junutula
Current opinion in molecular therapeutics (Print)
2010
Corpus ID: 24780622
Glembatumumab vedotin (CR-011-vc-MMAE) is a mAb-drug conjugate being developed by Celldex Therapeutics Inc for the treatment of…
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Highly Cited
2007
Highly Cited
2007
Biochemical characterization of a Neisseria meningitidis polysialyltransferase reveals novel functional motifs in bacterial sialyltransferases
Friedrich Freiberger
,
H. Claus
,
+7 authors
K. Stummeyer
Molecular Microbiology
2007
Corpus ID: 2377192
The extracellular polysaccharide capsule is an essential virulence factor of Neisseria meningitidis, a leading cause of severe…
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2007
2007
Role of human HGFIN/nmb in breast cancer
Rebecca L Metz
,
Prem S. Patel
,
M. Hameed
,
M. Bryan
,
P. Rameshwar
Breast Cancer Research
2007
Corpus ID: 5911364
IntroductionHGFIN, previously identified as nmb, and its homolog osteoactivin are single transmembrane proteins that are…
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Highly Cited
1996
Highly Cited
1996
Comparative Pharmacology of Cisatracurium (51W89), Atracurium, and Five Isomers in Cats
W. Wastila
,
R. Maehr
,
Geoffrey L. Turner
,
D. A. Hill
,
M. Phil
,
J. Savarese
Anesthesiology
1996
Corpus ID: 23963554
Background Atracurium has four chiral centers and the marketed product is a mixture of ten optical and geometric isomers. Six of…
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1992
1992
[Plasma-membrane fluidity studies of murine neuroblastoma and malignant melanoma cells under irradiation].
E. Busse
,
G. Zimmer
,
B. Kornhuber
Strahlentherapie und Onkologie (Print)
1992
Corpus ID: 20740503
Murine neuroblastoma (C-1300 NMB) and malignant melanoma (B16) cells were radiated in presence of radiopharmaceutics…
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