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Glembatumumab

Known as: Immunoglobulin G2, Anti-(Human Transmembrane Glycoprotein NMB (HGFIN) Extracellular Domain) Human Monoclonal CR011 Heavy Chain (133-215')-Disulfide with Human Monoclonal CR011 Kappa Light Chain, Dimer (221-221'':222-222'':225-225'':228- 228'')-Tetrakis, Immunoglobulin, Anti-(Human Glycoprotein NMB Extracellular Domain) (Human Monoclonal CR011 Heavy Chain), Disulfide with Human Monoclonal CR011 Gamma-2 Kappa-Chain, Dimer 
A human monoclonal antibody against transmembrane glycoprotein non-metastatic melanoma protein B (GPNMB). Glembatumumab binds to GPNMB on cancer… 
National Institutes of Health

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CR011
antigen binding

Papers overview

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2018
2018
Structure-activity study of furyl aryloxazole fluorescent probes for the detection of singlet oxygen
In this study, we report the synthesis and the photochemical behavior of a series of new "click-on" fluorescent probes designed… 
Review
2017
Review
2017
Novel Targeted Therapies for Metastatic Melanoma
Abstract Oncogene-targeted therapy is a major component of precision oncology, and although patients with metastatic melanoma… 
2016
2016
Identification of gamma-synuclein as a new PCBP1-interacting protein
Objectives: PolyC binding protein 1 (PCBP1) is a transcriptional regulator of human mu-opioid receptor (hMOR) gene in the CNS and… 
2016
2016
Abstract 4209: Targeting GPNMB with 89Zr-CR011 for PET imaging of triple negative breast cancer
Glycoprotein non-metastatic melanoma B (GPNMB) is a transmembrane protein overexpressed in 30 - 40% of triple negative breast… 
2014
2014
Abstract 3984: Elucidating expression patterns of GPNMB and potential anti-tumor effects of the antibody-drug conjugate, glembatumumab vedotin (CDX-011) in human osteosarcoma primary samples and cell…
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Despite numerous clinical trials to improve outcomes for… 
2013
2013
Hypoxia Regulates the Expression of the Neuromedin B Receptor through a Mechanism Dependent on Hypoxia-Inducible Factor-1α
The neuromedin B receptor (NMB-R), a member of the mammalian bombesin receptor family, is frequently overexpressed in various… 
2011
2011
Are we failing to prepare nurses in the UK and Australia to practice by the codes of conduct?
Nursing pre-registration curricula in the United Kingdom (UK) and Australia (Aust.) are underpinned by codes of conduct which… 
Highly Cited
2010
Highly Cited
2010
Glembatumumab vedotin, a conjugate of an anti-glycoprotein non-metastatic melanoma protein B mAb and monomethyl auristatin E for the treatment of melanoma and breast cancer.
Glembatumumab vedotin (CR-011-vc-MMAE) is a mAb-drug conjugate being developed by Celldex Therapeutics Inc for the treatment of… 
2006
2006
Quaternary derivatives of granatanol diesters: potent, ultrashort acting non-depolarizing neuromuscular relaxants.
1992
1992
[Plasma-membrane fluidity studies of murine neuroblastoma and malignant melanoma cells under irradiation].
Murine neuroblastoma (C-1300 NMB) and malignant melanoma (B16) cells were radiated in presence of radiopharmaceutics… 
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