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Glembatumumab

Known as: Immunoglobulin G2, Anti-(Human Transmembrane Glycoprotein NMB (HGFIN) Extracellular Domain) Human Monoclonal CR011 Heavy Chain (133-215')-Disulfide with Human Monoclonal CR011 Kappa Light Chain, Dimer (221-221'':222-222'':225-225'':228- 228'')-Tetrakis, Immunoglobulin, Anti-(Human Glycoprotein NMB Extracellular Domain) (Human Monoclonal CR011 Heavy Chain), Disulfide with Human Monoclonal CR011 Gamma-2 Kappa-Chain, Dimer 
A human monoclonal antibody against transmembrane glycoprotein non-metastatic melanoma protein B (GPNMB). Glembatumumab binds to GPNMB on cancer… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Glembatumumab vedotin is an antibody‐drug conjugate that produced preliminary clinical activity against advanced melanoma in a… Expand
2016
2016
Objectives: PolyC binding protein 1 (PCBP1) is a transcriptional regulator of human mu-opioid receptor (hMOR) gene in the CNS and… Expand
Review
2016
Review
2016
ABSTRACT Antibody-drug conjugates (ADCs) represent a new class of cancer therapeutics. Their design involves a tumor-specific… Expand
Highly Cited
2015
Highly Cited
2015
PURPOSE Glycoprotein NMB (gpNMB), a negative prognostic marker, is overexpressed in multiple tumor types. Glembatumumab vedotin… Expand
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2014
2014
Glembatumumab vedotin is an antibody‐auristatin conjugate that targets cells expressing the transmembrane glycoprotein NMB (GPNMB… Expand
Highly Cited
2010
Highly Cited
2010
Glembatumumab vedotin (CR-011-vc-MMAE) is a mAb-drug conjugate being developed by Celldex Therapeutics Inc for the treatment of… Expand
Highly Cited
2007
Highly Cited
2007
The extracellular polysaccharide capsule is an essential virulence factor of Neisseria meningitidis, a leading cause of severe… Expand
2007
2007
IntroductionHGFIN, previously identified as nmb, and its homolog osteoactivin are single transmembrane proteins that are… Expand
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Highly Cited
1996
Highly Cited
1996
Background Atracurium has four chiral centers and the marketed product is a mixture of ten optical and geometric isomers. Six of… Expand
1992
1992
Murine neuroblastoma (C-1300 NMB) and malignant melanoma (B16) cells were radiated in presence of radiopharmaceutics… Expand