Genetic Pleiotropy

Known as: Genetic Pleiotropism, Pleiotropism, Genetic, Pleiotropy, Genetic 
A phenomenon in which multiple and diverse phenotypic outcomes are influenced by a single gene (or single gene product.)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Editorial summary Several recent papers have used summary results from genome-wide association studies to characterize genetic… (More)
Is this relevant?
2015
2015
Genetic pleiotropy, the phenomenon by which mutations in the same gene result in markedly different disease phenotypes, has… (More)
  • figure 4
  • figure 4
Is this relevant?
Highly Cited
2015
Highly Cited
2015
Converging evidence implicates immune abnormalities in schizophrenia (SCZ), and recent genome-wide association studies (GWAS… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • table 2
Is this relevant?
2014
2014
Blood pressure is a critical determinant of cardiovascular morbidity and mortality. It is affected by environmental factors, but… (More)
  • figure 1
  • figure 2
  • table 1
  • table 2
Is this relevant?
2013
2013
An important task of human genetics studies is to predict accurately disease risks in individuals based on genetic markers, which… (More)
  • figure 1
  • figure 4
  • figure 6
  • figure 8
  • figure 9
Is this relevant?
2012
2012
Musculoskeletal aging is detrimental to multiple bodily functions and starts early, probably in the fourth decade of an… (More)
  • table 1
  • figure 1
  • figure 2
Is this relevant?
Highly Cited
2012
Highly Cited
2012
Antagonistic pleiotropy (AP), or genetic tradeoff, is an important concept that is frequently invoked in theories of aging… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 6
Is this relevant?
Review
2010
Review
2010
A half century ago, the antagonistic pleiotropy (AP) theory had solved a mystery of aging, by postulating genes beneficial early… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
2009
2009
Quantitative genetic approaches have been developed that allow researchers to determine which of two mechanisms, mutation… (More)
  • table 1
  • figure 1
  • figure 2
Is this relevant?
Highly Cited
2005
Highly Cited
2005
BACKGROUND Asthma and obesity are common conditions that are strongly associated. This association might be due to shared genetic… (More)
Is this relevant?