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Gamma-Glutamyl Hydrolase, human

Known as: Gamma-Glu-X Carboxypeptidase, EC 3.4.19.9, Gamma-Glutamyl Hydrolase 
Gamma-glutamyl hydrolase (318 aa, ~36 kDa) is encoded by the human GGH gene. This protein is involved in the hydrolysis of gamma-linked glutamate… 
National Institutes of Health

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Related topics

10 relations
Enzyme GeneExtracellular SpaceFolate Biosynthesis PathwayGGH gene

Broader (1)

gamma-Glutamyl Hydrolase

Papers overview

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2016
2016
Molecular Factors Associated with Pemetrexed Sensitivity According to Histological Type in Non-small Cell Lung Cancer.
BACKGROUND This study was designed to investigate potential molecules that predict chemosensitivity to pemetrexed (Alimta®) in… 
2014
2014
Inactivation of sortase A mediated by metal ATCUN complexes
Catalytic metallopeptides that target the membrane-associated sortase A transpeptidase have been developed and evaluated as… 
2008
2008
Mechanism-based inhibitors of folylpoly-gamma-glutamate synthetase and gamma-glutamyl hydrolase: control of folylpoly-gamma-glutamate homeostasis as a drug target.
2002
2002
Three-dimensional structure of human gamma -glutamyl hydrolase. A class I glatamine amidotransferase adapted for a complex substate.
gamma-Glutamyl hydrolase catalyzes the cleavage of the gamma-glutamyl chain of folylpoly-gamma-glutamyl substrates and is a… 
2000
2000
Molecular modeling and site-directed mutagenesis define the catalytic motif in human gamma -glutamyl hydrolase.
Human gamma-glutamyl hydrolase (hGH) is a central enzyme in folyl and antifolylpoly-gamma-glutamate metabolism, which functions… 
1993
1993
The properties and function of gamma-glutamyl hydrolase and poly-gamma-glutamate.
gamma-Glutamyl hydrolase is a ubiquitous enzyme that has the capacity to cleave gamma-glutamyl bonds of cellular folyl- and… 
1990
1990
Synthesis of N-[N-(4-deoxy-4-amino-10-methylpteroyl)-4-fluoroglutamyl]- gamma-glutamate, an unusual substrate for folylpoly-gamma-glutamate synthetase and gamma-glutamyl hydrolase.
N-[N-(4-Deoxy-4-amino-10-methylpteroyl)-4-fluoroglutamyl]-ga mma-glutamate has been synthesized and its ability to serve as a… 
1988
1988
The measurement of gamma-glutamyl hydrolase (conjugase) activity in rat brain
An assay using the artificial substrate, 2,4-diamino-10-methyl-pteroylglutamyl-gamma-glutamate (MTX-G1), was developed to measure… 
1975
1975
Folic acid conjugase from plasma. III. Use of the enzyme in the estimation of folate activity in foods.
A convenient method for the estimation of food folates using human plasma as a source of folic acid conjugase has been… 
1969
1969
Folic Acid Conjugase
Summary Evidence is presented to show inhibition of guinea pig intestinal mucosa gamma glutamyl carboxypeptidase (conjugase) by… 
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