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GW1100

 
National Institutes of Health

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2 relations

Broader (2)

BenzoatesPyrimidines

Papers overview

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2018
2018
GPR40 is a low-affinity epoxyeicosatrienoic acid receptor in vascular cells
Endothelium-derived epoxyeicosatrienoic acids (EETs) have numerous vascular activities mediated by G protein–coupled receptors… Expand
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2017
2017
Omega-3 fatty acids regulate NLRP3 inflammasome activation and prevent behavior deficits after traumatic brain injury
&NA; Omega‐3 fatty acids (&ohgr; − 3 FAs) attenuate inflammation and improve neurological outcome in response to traumatic brain… Expand
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2017
2017
Chylomicrons stimulate incretin secretion in mouse and human cells
Aims/hypothesisLipids are a potent stimulus for the secretion of glucagon-like peptide (GLP)-1 and glucose-dependent… Expand
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2016
2016
Diverse effects of G-protein-coupled free fatty acid receptors on the regulation of cellular functions in lung cancer cells.
Free fatty acids (FFAs) are dietary nutrients which mediate a variety of biological effects through binding to G-protein-coupled… Expand
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2015
2015
The activation of supraspinal GPR40/FFA1 receptor signalling regulates the descending pain control system.
BACKGROUND AND PURPOSE The ω-3 polyunsaturated fatty acids exert antinociceptive effects in inflammatory and neuropathic pain… Expand
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2015
2015
The Anthocyanin Delphinidin 3-Rutinoside Stimulates Glucagon-Like Peptide-1 Secretion in Murine GLUTag Cell Line via the Ca2+/Calmodulin-Dependent Kinase II Pathway
Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted from enteroendocrine L-cells. Although several nutrients induce… Expand
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2015
2015
Tumor necrosis factor α decreases glucagon-like peptide-2 expression by up-regulating G-protein-coupled receptor 120 in Crohn disease.
Glucagon-like peptide (GLP)-2, secreted by L cells in the small intestine, has anti-inflammatory effects in the gastrointestinal… Expand
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2015
2015
Regulation of prohormone convertase 2 protein expression via GPR40/FFA1 in the hypothalamus.
Previous studies have shown that the administration of docosahexaenoic acid (DHA) or GW9508, a GPR40/FFA1 (free fatty acid… Expand
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2013
2013
Hypothalamic GPR40 Signaling Activated by Free Long Chain Fatty Acids Suppresses CFA-Induced Inflammatory Chronic Pain
GPR40 has been reported to be activated by long-chain fatty acids, such as docosahexaenoic acid (DHA). However, reports studying… Expand
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Highly Cited
2006
Highly Cited
2006
Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules.
1. Long chain fatty acids have recently been identified as agonists for the G protein-coupled receptors GPR40 and GPR120. Here… Expand
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