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GW1100

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2006-2017
024620062017

Related topics

Related topics

2 relations

Broader (2)

BenzoatesPyrimidines

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
GW1100
Pyrimidines
Benzoates

Papers overview

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2017
2017
Omega-3 fatty acids regulate NLRP3 inflammasome activation and prevent behavior deficits after traumatic brain injury.
Omega-3 fatty acids (ω-3 FAs) attenuate inflammation and improve neurological outcome in response to traumatic brain injury (TBI… (More)
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2016
2016
Diverse effects of G-protein-coupled free fatty acid receptors on the regulation of cellular functions in lung cancer cells.
Free fatty acids (FFAs) are dietary nutrients which mediate a variety of biological effects through binding to G-protein-coupled… (More)
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2016
2016
Differential intracellular calcium influx, nitric oxide production, ICAM-1 and IL8 expression in primary bovine endothelial cells exposed to nonesterified fatty acids.
BACKGROUND Nonesterified fatty acids (NEFAs) are involved in proinflammatory processes in cattle, including in the increased… (More)
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2015
2015
The Anthocyanin Delphinidin 3-Rutinoside Stimulates Glucagon-Like Peptide-1 Secretion in Murine GLUTag Cell Line via the Ca2+/Calmodulin-Dependent Kinase II Pathway
Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted from enteroendocrine L-cells. Although several nutrients induce… (More)
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2015
2015
Opposite effects of GPR120 and GPR40 on cell motile activity induced by ethionine in liver epithelial cells.
Free fatty acids (FFAs) are dietary nutrients which act as ligands for FFAs receptors. G-protein-coupled receptor 120 (GPR120… (More)
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2015
2015
Tumor necrosis factor α decreases glucagon-like peptide-2 expression by up-regulating G-protein-coupled receptor 120 in Crohn disease.
Glucagon-like peptide (GLP)-2, secreted by L cells in the small intestine, has anti-inflammatory effects in the gastrointestinal… (More)
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2013
2013
Hypothalamic GPR40 Signaling Activated by Free Long Chain Fatty Acids Suppresses CFA-Induced Inflammatory Chronic Pain
GPR40 has been reported to be activated by long-chain fatty acids, such as docosahexaenoic acid (DHA). However, reports studying… (More)
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2011
2011
Feasible Synthesis of Antagonist of GPR40 by Constructing 2-Thiouracil Ring viaAcid Mediated Cyclization.
GW1100 is an antagonist of GPR40 identified by high throughput screening recently. The synthesis of GW1100 has been developed… (More)
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2007
2007
Uncovering the Pharmacology of the G Protein-Coupled Receptor GPR40: High Apparent Constitutive Activity in Guanosine 5 -O-(3-[S]thio)triphosphate Binding Studies Reflects Binding of an Endogenous…
In cells lacking expression of Ca -mobilizing G proteins, coexpression of human GPR40 and G q allowed mediumand long-chain fatty… (More)
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Highly Cited
2006
Highly Cited
2006
Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules.
1. Long chain fatty acids have recently been identified as agonists for the G protein-coupled receptors GPR40 and GPR120. Here… (More)
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