GTF2B protein, human

Known as: RNA Polymerase II Transcription Factor IIB, Transcription Initiation Factor IIB, General Transcription Factor TFIIB 
Transcription initiation factor IIB (316 aa, ~95 kDa) is encoded by the human GTF2B gene. This protein plays a role in the initiation of RNA… (More)
National Institutes of Health

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9 relations
Basal transcription factor genesChromatin Remodeling Complex and Coactivator PathwayDNA-Binding ProteinsGTF2B gene
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Papers overview

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Highly Cited
2010
Highly Cited
2010
Structure of an RNA polymerase II-TFIIB complex and the transcription initiation mechanism.
Previous x-ray crystal structures have given insight into the mechanism of transcription and the role of general transcription… (More)
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2010
2010
Phosphorylation of TFIIB Links Transcription Initiation and Termination
The general transcription factor TFIIB plays a central role in preinitiation complex (PIC) assembly and the recruitment of RNA… (More)
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2008
2008
Functional characterization of the native NH2-terminal transactivation domain of the human androgen receptor: binding kinetics for interactions with TFIIF and SRC-1a.
The androgen receptor (AR) is a ligand-activated transcription factor that mediates the actions of the steroid hormones… (More)
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2004
2004
A nonconserved surface of the TFIIB zinc ribbon domain plays a direct role in RNA polymerase II recruitment.
The general transcription factor TFIIB is a highly conserved and essential component of the eukaryotic RNA polymerase II (pol II… (More)
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Highly Cited
2001
Highly Cited
2001
General transcription factors bind promoters repressed by Polycomb group proteins
To maintain cell identity during development and differentiation, mechanisms of cellular memory have evolved that preserve… (More)
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2001
2001
Activator-mediated disruption of sequence-specific DNA contacts by the general transcription factor TFIIB.
The transcription factor TFIIB plays a central role in preinitiation complex assembly, providing a bridge between promoter-bound… (More)
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Highly Cited
1992
Highly Cited
1992
Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II).
The S300-II factor was discovered as an activator of ovalbumin gene transcription with the chicken ovalbumin upstream promoter… (More)
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Highly Cited
1989
Highly Cited
1989
COUP transcription factor is a member of the steroid receptor superfamily
THE COUP (chicken ovalbumin upstream promoter) transcription factor (COUP-TF) exists in a number of different tissues and is… (More)
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1987
1987
Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II)
We have identified previously two transcription factors, COUP (chicken ovalbumin upstream promoter) and S300-II, from HeLa cell… (More)
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1986
1986
Identification of two factors required for transcription of the ovalbumin gene.
Two transcription factors, COUP and S300-II, were isolated and partially purified from HeLa cell nuclear extracts. Both factors… (More)
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