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GRL 8234

Known as: GRL-8234, GRL8234 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Phthalic AcidsSulfonamides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Cognitive benefits of memantine in Alzheimer's 5XFAD model mice decline during advanced disease stages
  • L. DeviM. Ohno
  • Pharmacology, Biochemistry and Behavior
  • 2016
  • Corpus ID: 207333502
2015
2015
Beneficial effects of the β-secretase inhibitor GRL-8234 in 5XFAD Alzheimer's transgenic mice lessen during disease progression.
The β-secretase enzyme BACE1, which initiates the cleavage of amyloid precursor protein (APP) into the amyloid-β (Aβ) peptide, is… 
Highly Cited
2011
Highly Cited
2011
β‐Secretase inhibitor GRL‐8234 rescues age‐related cognitive decline in APP transgenic mice
Alzheimer disease is intimately linked to an excess amount of amyloid‐β (Aβ) in the brain. Thus, therapeutic inhibition of A… 
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