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Endothelium-leukocyte interaction is critical for inflammatory responses. Whereas the tissue microenvironments are often acidic… Expand The renal collecting system serves the fine-tuning of renal acid–base secretion. Acid-secretory type-A intercalated cells secrete… Expand The Galpha protein Gpa1 governs the cAMP-PKA signaling pathway and plays a central role in virulence and differentiation in the… Expand ABSTRACT GPR4 is a G protein-coupled receptor expressed in the vasculature, lung, kidney, and other tissues. In vitro ectopic… Expand G protein coupled receptors (GPCRs) form homo- and hetero-dimers or -oligomers, which are functionally important… Expand Abundant evidence indicates that lysophosphatidylcholine (LPC) is proinflammatory and atherogenic. In the vascular endothelium… Expand OGR1, GPR4, G2A, and TDAG8 share 40% to 50% homology with each other and seem to form a family of GPCRs. They have been described… Expand The GPR4 subfamily consists of four G protein-coupled receptors that share significant sequence homology. In addition to GPR4… Expand Blood pH is maintained in a narrow range around pH 7.4 mainly through regulation of respiration and renal acid extrusion. The… Expand Sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC) are bioactive lipid molecules involved in numerous biological… Expand