GPC3 protein, human

Known as: glypican 3 protein, human, MXR7 protein, human, Intestinal Protein OCI-5 
Glypican-3 (580 aa, ~66 kDa) is encoded by the human GPC3 gene. This protein is involved in the mediation of proteoglycan binding to the cell surface… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1974-2018
0204019742018

Papers overview

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Highly Cited
2009
Highly Cited
2009
The relationship between overexpression of glypican (GPC)-3 that is specific for hepatocellular carcinoma (HCC) and the prognosis… (More)
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Highly Cited
2008
Highly Cited
2008
Loss-of-function mutations in glypican-3 (GPC3), one of the six mammalian glypicans, causes the Simpson-Golabi-Behmel overgrowth… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND & AIMS Small liver nodules approximately 2 cm are difficult to characterize by radiologic or pathologic examination… (More)
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Highly Cited
2006
Highly Cited
2006
Distinguishing small hepatocellular carcinoma (HCC) from other types of small focal lesions that occur in a cirrhotic liver can… (More)
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Highly Cited
2005
Highly Cited
2005
Glypican-3 (GPC3) is a heparan sulfate proteoglycan that is bound to the cell membrane by a glycosyl-phosphatidylinositol anchor… (More)
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Highly Cited
2005
Highly Cited
2005
Loss-of-function mutations of the GPC3 gene are the cause of the human Simpson-Golabi-Behmel syndrome. Based on the overgrowth… (More)
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Highly Cited
2004
Highly Cited
2004
For detection of hepatocellular carcinoma (HCC) in patients with liver cirrhosis, serum alpha-fetoprotein has been widely used… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND & AIMS Early detection of hepatocellular carcinoma (HCC) is critical for successful treatment. However, the… (More)
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Highly Cited
2003
Highly Cited
2003
With the global pandemic of hepatitis B and C infections, the incidence of Hepatocellular carcinoma (HCC) is rapidly increasing… (More)
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Highly Cited
2003
Highly Cited
2003
The Glypican (GPC) family is a prototypical member of the cell-surface heparan sulfate proteoglycans (HSPGs). The HSPGs have been… (More)
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