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GPC3 protein, human

Known as: glypican 3 protein, human, MXR7 protein, human, Intestinal Protein OCI-5 
Glypican-3 (580 aa, ~66 kDa) is encoded by the human GPC3 gene. This protein is involved in the mediation of proteoglycan binding to the cell surface… 
National Institutes of Health

Related topics

Related topics

6 relations
GPC3 geneGPC3 wt AlleleLigand BindingPlasma membrane

Broader (2)

Glypicanglypican 3

Papers overview

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2016
2016
Abstract 1686: Glypican-3 (GPC3) induces a mesenchymal-epithelial transition in human breast cancer cells lines
Glypicans constitute a family of heparan sulphate proteoglycans which are linked to the extracellular surface of the plasma… 
2015
2015
Abstract 3256: Glypican-3 (GPC3) inhibits the metastasis development in a murine breast cancer model through the activation of p38MAPK signaling pathway
GPC3 reexpression into the murine mammary adenocarcinoma LM3 cells (GPC3 negative) induced an inhibition of the metastatic… 
2015
2015
Abstract 1419: Glypican-3 (GPC3) inhibits metastatic dissemination in a preclinical human breast cancer model
Although GPC3 has been linked to cancer, its role during mammary tumor progression is barely known. With the aim to develop a pre… 
2013
2013
[Short hairpin RNA mediated glypican-3 silencing inhibits hepatoma cell invasiveness and disrupts molecular pathways of angiogenesis].
OBJECTIVE To construct glypican-3 (GPC-3) short hairpin RNA (shRNA) and investigate the effects of GPC-3 transcription silencing… 
2010
2010
Up-regulation of glypican-3 in human hepatocellular carcinoma.
AIM To investigate the expression and significance of glypican-3 (GPC3) in human hepatocellular carcinoma (HCC). MATERIALS AND… 
2008
2008
Glypican-3 antibodies with improved kinetic plasma values
FIELD: medicine. SUBSTANCE: invention presents a glypican-3 antibody, an anticancer composition, an anticancer drug containing… 
2007
2007
In vivo footprinting analysis of the Glypican 3 (GPC3) promoter region in neuroblastoma cells.
2003
2003
Growth promotion of HepG2 hepatoma cells by antisense-mediated knockdown of glypican-3 is independent of insulin-like growth factor 2 signaling
Glypican-3 (GPC3) encodes a cell-surface heparan-sulfate proteoglycan and its expression is frequently silenced in ovarian cancer… 
1999
1999
Selection of a high activity ribozyme against cytostatic drug resistance-associated glypican-3 using an in vitro assay containing total tumor RNA
We tested 11 hammerhead ribozymes for their ability to bind and cleave RNA transcripts of the cytostatic drug resistance… 
1998
1998
Expression of the novel mitoxantrone resistance associated gene MXR7 in colorectal malignancies.
It was shown previously that a glypican encoding gene (MXR7/GPC3/OCl-5) was associated with mitoxantrone resistance in vitro… 
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