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GP1BA protein, human

Known as: Antigen CD42b-Alpha, Glycoprotein Ibalpha, glycoprotein Ib (platelet), alpha polypeptide, human 
Platelet glycoprotein Ib alpha chain (652 aa, ~72 kDa) is encoded by the human GP1BA gene. This protein plays a role in von Willebrand factor binding… Expand
National Institutes of Health

Related topics

Related topics

13 relations
Blood PlateletsCD42 ComplexCD42b AntigenGP1BA gene
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Broader (1)

adhesion receptor

Papers overview

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Highly Cited
2008
Highly Cited
2008
Platelet granule secretion continuously prevents intratumor hemorrhage.
Cancer is associated with a prothrombogenic state capable of platelet activation. Platelets, on the other hand, can support… Expand
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Highly Cited
2008
Highly Cited
2008
Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF.
Arterial blood flow enhances glycoprotein Ibalpha (GPIbalpha) binding to vWF, which initiates platelet adhesion to injured… Expand
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Highly Cited
2006
Highly Cited
2006
Mechanism of platelet adhesion to von Willebrand factor and microparticle formation under high shear stress.
We describe here the mechanism of platelet adhesion to immobilized von Willebrand factor (VWF) and subsequent formation of… Expand
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Highly Cited
2005
Highly Cited
2005
A novel nanobody that detects the gain-of-function phenotype of von Willebrand factor in ADAMTS13 deficiency and von Willebrand disease type 2B.
Von Willebrand factor (VWF) is unable to interact spontaneously with platelets because this interaction requires a conversion of… Expand
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Highly Cited
2004
Highly Cited
2004
Crystal Structure of the Wild-type von Willebrand Factor A1-Glycoprotein Ibα Complex Reveals Conformation Differences with a Complex Bearing von Willebrand Disease Mutations*
The adhesion of platelets to the subendothelium of blood vessels at sites of vascular injury under high shear conditions is… Expand
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Highly Cited
2003
Highly Cited
2003
Crystal Structure of the GpIbα-Thrombin Complex Essential for Platelet Aggregation
Direct interaction between platelet receptor glycoprotein Ibα (GpIbα) and thrombin is required for platelet aggregation and… Expand
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Highly Cited
2002
Highly Cited
2002
Structures of Glycoprotein Ibα and Its Complex with von Willebrand Factor A1 Domain
Transient interactions of platelet-receptor glycoprotein Ibα (GpIbα) and the plasma protein von Willebrand factor (VWF) reduce… Expand
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Highly Cited
2000
Highly Cited
2000
Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins.
With the use of intravital microscopy, a new type of platelet-endothelial interaction in mouse mesenteric venules at low shear… Expand
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Highly Cited
1999
Highly Cited
1999
Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules.
Platelet activation leads to secretion of granule contents and to the formation of microvesicles by shedding of membranes from… Expand
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Highly Cited
1998
Highly Cited
1998
Polymorphisms of platelet membrane glycoprotein Ib associated with arterial thrombotic disease.
Platelet membrane glycoprotein Ibalpha (GPIbalpha) is a major receptor for von Willebrand factor and thrombin, which plays a key… Expand
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