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GNE-618

National Institutes of Health

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Broader (2)

PyrazolesSulfones

Papers overview

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2014
2014
Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors
Inhibiting NAD biosynthesis by blocking the function of nicotinamide phosphoribosyl transferase (NAMPT) is an attractive… 
Highly Cited
2013
Highly Cited
2013
Dependence of tumor cell lines and patient-derived tumors on the NAD salvage pathway renders them sensitive to NAMPT inhibition with GNE-618.
Nicotinamide adenine dinucleotide (NAD) is a critical metabolite that is required for a range of cellular reactions. A key enzyme… 
2013
2013
Supplementation of nicotinic acid with NAMPT inhibitors results in loss of in vivo efficacy in NAPRT1-deficient tumor models.
Nicotinamide adenine dinucleotide (NAD) is a metabolite essential for cell survival and generated de novo from tryptophan or… 
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