GNAQ gene

Known as: GUANINE NUCLEOTIDE-BINDING PROTEIN, Q POLYPEPTIDE, G protein subunit alpha q, G-ALPHA-q 
This gene plays a role in signal transduction and is involved in calcium signaling.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1953-2018
0204019532017

Papers overview

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Highly Cited
2014
Highly Cited
2014
Mutually exclusive activating mutations in the GNAQ and GNA11 oncogenes, encoding heterotrimeric Gαq family members, have been… (More)
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2014
2014
Circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) have been recently investigated in several cancer types, but… (More)
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2012
2012
PURPOSE Activating Q209L/P mutations in GNAQ or GNA11 (GNAQ/11) are present in approximately 80% of uveal melanomas. Mutant GNAQ… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Uveal melanoma is the most common intraocular cancer. There are no effective therapies for metastatic disease… (More)
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Highly Cited
2009
Highly Cited
2009
BRAF and NRAS are common targets for somatic mutations in benign and malignant neoplasms that arise from melanocytes situated in… (More)
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Highly Cited
2009
Highly Cited
2009
Background:Recently, oncogenic G protein alpha subunit q (GNAQ) mutations have been described in about 50% of uveal melanomas and… (More)
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2009
2009
Primary melanocytic neoplasms of the central nervous system (CNS) are uncommon neoplasms derived from melanocytes that normally… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE Early/initiating oncogenic mutations have been identified for many cancers, but such mutations remain unidentified in… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Chronic stress has significant effects on hippocampal structure and function. We have previously identified nerve… (More)
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Highly Cited
2001
Highly Cited
2001
Vardenafil, a novel selective phosphodiesterase type 5 inhibitor, was evaluated in its first large-scale at-home trial. A total… (More)
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