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GNAO1 gene

Known as: GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-ACTIVATING ACTIVITY POLYPEPTIDE O, GNAO, G-ALPHA-o 
This gene is involved in the modulation of G protein signaling.
National Institutes of Health

Related topics

Related topics

8 relations
Environment-to-Cell CommunicationG Protein-Coupled Receptor SignalingGNAL geneGTP Binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Genetic heterogeneity in infantile spasms
Review
2019
Review
2019
Phenomenology and clinical course of movement disorder in GNAO1 variants: Results from an analytical review.
Review
2017
Review
2017
GNAO1-related movement disorder with life-threatening exacerbations: movement phenomenology and response to DBS
GNAO1 (OMIM 139311) encodes a GαCNS protein responsible for regulation of GABA-B and α2-receptors, and neurotransmitter release… 
Highly Cited
2017
Highly Cited
2017
Movement disorder in GNAO1 encephalopathy associated with gain-of-function mutations
Objective: To define molecular mechanisms underlying the clinical spectrum of epilepsy and movement disorder in individuals with… 
Highly Cited
2015
Highly Cited
2015
Phenotypic spectrum of GNAO1 variants: epileptic encephalopathy to involuntary movements with severe developmental delay
De novo GNAO1 variants have been found in four patients including three patients with Ohtahara syndrome and one patient with… 
Highly Cited
2013
Highly Cited
2013
POSTER PRESENTATION Open Access
number of unobserved words), and show that the posterior mean can be efficiently computed via a simple numerical integral. The… 
Highly Cited
2013
Highly Cited
2013
De Novo mutations in GNAO1, encoding a Gαo subunit of heterotrimeric G proteins, cause epileptic encephalopathy.
Highly Cited
2013
Highly Cited
2013
Molecular network and chemical fragment-based characteristics of medicinal herbs with cold and hot properties from Chinese medicine.
Highly Cited
2011
Highly Cited
2011
Molecular basis of a novel oncogenic mutation in GNAO1
Heterotrimeric G proteins are molecular switches that control signal transduction, and their dysregulation can promote… 
Review
2010
Review
2010
Diverse somatic mutation patterns and pathway alterations in human cancers.
The systematic characterization of somatic mutations in cancer genomes is essential for understanding the disease and for… 
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