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GM-K562 cell vaccine

A cell-based vaccine comprised of K562 cells transfected with the granulocyte macrophage-colony stimulating factor (GM-CSF) gene with potential… 
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Exosomes released by K562 chronic myeloid leukemia cells promote angiogenesis in a src-dependent fashion
Exosomes, microvesicles of endocytic origin released by normal and tumor cells, play an important role in cell-to-cell… 
Highly Cited
2005
Highly Cited
2005
Involvement of PKC and ROS in the cytotoxic mechanism of anti-leukemic decursin and its derivatives and their structure-activity relationship in human K562 erythroleukemia and U937 myeloleukemia…
2002
2002
Quantitative analysis of a MDR1 transcript for prediction of drug resistance in acute leukemia.
BACKGROUND Assessing the drug resistance of leukemic cells is important for treatment of leukemia. We developed a quantitative… 
Highly Cited
1998
Highly Cited
1998
Heat Shock Response and Protein Degradation: Regulation of HSF2 by the Ubiquitin-Proteasome Pathway
ABSTRACT Mammalian cells coexpress a family of heat shock factors (HSFs) whose activities are regulated by diverse stress… 
Highly Cited
1998
Highly Cited
1998
Reduced folate carrier gene expression in childhood acute lymphoblastic leukemia: relationship to immunophenotype and ploidy.
Reduced folate carrier (RFC) transcripts in human leukemias were measured by a competitive PCR assay. Total RNAs were reverse… 
Highly Cited
1995
Highly Cited
1995
Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression
Fas/APO-1 is a cell surface protein known to trigger apoptosis upon specific antibody engagement. Because wild-type p53 can… 
Highly Cited
1995
Highly Cited
1995
Regulation of the Fas Apoptotic Cell Death Pathway by Abl (*)
Relatively little is known about oncogene involvement in the regulation of Fas-mediated apoptosis. Inhibition of Fas-induced cell… 
Highly Cited
1994
Highly Cited
1994
Recombinant adeno-associated virus-mediated gene transfer into hematopoietic progenitor cells.
Recombinant adeno-associated viruses (rAAV) containing only the inverted terminal repeats (ITR) from the wild-type virus are… 
Highly Cited
1994
Highly Cited
1994
Altered stability of etoposide-induced topoisomerase II-DNA complexes in resistant human leukaemia K562 cells.
K562 leukaemia cells were selected for resistance using 0.5 microM etoposide (VP-16). Cloned K/VP.5 cells were 30-fold resistant… 
Highly Cited
1991
Highly Cited
1991
Autologous transfusion: An alternative to transfusion with banked blood during surgery for cancer
Autologous blood transfusion in surgery for cancer has been avoided because of the metastatic potential of reinfused malignant… 
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