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Significance In various animal species, including mammals, longevity can be extended by rapamycin, an inhibitor of mTOR… Expand Growth hormone receptor knockout (GHR-KO) mice are long lived with improved health span, making this an excellent model system… Expand GH receptor (GHR) and prolactin (PRL) receptor (PRLR) are homologous transmembrane cytokine receptors. Each prehomodimerizes and… Expand Growth hormone deficiency is considered the most important factor determining skeletal fragility in hypopituitary patients… Expand It has been reported that nuclear translocation of growth hormone receptor (GHR) may directly activate cell proliferation in… Expand Brain cytochrome P450 2D (CYP2D) metabolises exogenous neurotoxins, endogenous substances and neurotransmitters. Brain CYP2D can… Expand Genetic suppression of insulin/insulin-like growth factor signaling (IIS) can extend longevity in worms, insects, and mammals. In… Expand The GH receptor (GHR) mediates GH effects by activating the GHR-associated cytoplasmic tyrosine kinase, Janus kinase 2. Recent… Expand There is conflicting information on the physiological role of growth hormone (GH) in the control of aging. This study reports… Expand