GDC-0425

Known as: Chk1 Inhibitor GDC-0425 
An orally bioavailable inhibitor of checkpoint kinase 1 (chk1), with potential antineoplastic and chemosensitization activities. Upon oral… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2015-2017
01220152017

Papers overview

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2017
2017
GDC-0425 [5-((1-ethylpiperidin-4-yl)oxy)-9H-pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile] is an orally bioavailable small… (More)
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2017
2017
Purpose: Chk1 inhibition potentiates DNA-damaging chemotherapy by overriding cell-cycle arrest and genome repair. This phase I… (More)
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2016
2016
A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of GDC-0425 concentrations in human… (More)
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2015
2015
Young G. Shin*, Henri Meijering*, Fred H. van Heuveln, Jaap Wieling, Jason Halladay, Srikumar Sahasranaman and Cornelis E.C.A… (More)
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