GABRA1 gene

OBJECTIVE To determine the genes underlying Dravet syndrome in patients who do not have an SCN1A mutation on routine testing… (More)

Gamma-aminobutyric acid A (GABA(A)) receptors are ligand-gated ion channels responsible for mediation of fast inhibitory action… (More)

BACKGROUND A wealth of literature supports the role of gamma-aminobutyric acid (GABA) in neurobiological pathways contributing to… (More)

OBJECTIVE To detect mutations in GABRA1 in idiopathic generalized epilepsy. METHODS GABRA1 was sequenced in 98 unrelated… (More)

The gamma-aminobutyric acid A (GABA-A) receptor mediates inhibitory neurotransmission in the brain and as such may be involved in… (More)

Juvenile myoclonic epilepsy (JME), accounting for approximately 25% of idiopathic generalized epilepsies, is genetically… (More)

Autism is a common neurodevelopmental disorder with a significant genetic component. Existing research suggests that multiple… (More)

We previously performed a genome-wide linkage scan in Portuguese schizophrenia families that identified a risk locus on… (More)

BACKGROUND The gamma-aminobutyric acid (GABA) neurotransmitter system has been implicated in the pathogenesis of mood disorders… (More)

Although many genes that predispose for epilepsy in humans have been determined, those that underlie the classical syndromes of… (More)