G-Protein-Coupled Receptor Kinases

Known as: GRK, G-Protein-Coupled Receptor Kinases [Chemical/Ingredient], G Protein-Coupled Receptor Kinase 
A family of serine-threonine kinases that are specific for G-PROTEIN-COUPLED RECEPTORS. They are regulatory proteins that play a role in G-protein… (More)
National Institutes of Health

Papers overview

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Review
2012
Review
2012
G protein-coupled receptor (GPCR) kinases (GRKs) are best known for their role in homologous desensitization of GPCRs. GRKs… (More)
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Highly Cited
2009
Highly Cited
2009
CCL19 and CCL21 are endogenous agonists for the seven-transmembrane receptor CCR7. They are equally active in promoting G protein… (More)
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Review
2007
Review
2007
G protein-coupled receptor kinases (GRKs) and arrestins are key participants in the canonical pathways leading to phosphorylation… (More)
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Highly Cited
2005
Highly Cited
2005
Signaling through beta-arrestins is a recently appreciated mechanism used by seven-transmembrane receptors. Because G protein… (More)
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Review
2002
Review
2002
beta-Arrestins are versatile adapter proteins that form complexes with most G-protein-coupled receptors (GPCRs) following agonist… (More)
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Highly Cited
2002
Highly Cited
2002
Essential hypertension has a heritability as high as 30-50%, but its genetic cause(s) has not been determined despite intensive… (More)
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Highly Cited
1999
Highly Cited
1999
G protein-coupled receptor kinases (GRKs) have been principally characterized by their ability to phosphorylate and desensitize G… (More)
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Highly Cited
1997
Highly Cited
1997
Impaired vascular beta-adrenergic responsiveness may play an important role in the development and/or maintenance of hypertension… (More)
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Highly Cited
1996
Highly Cited
1996
Transgenic mice were generated with cardiac-specific overexpression of the G protein-coupled receptor kinase-5 (GRK5), a serine… (More)
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Review
1995
Review
1995
G protein-coupled receptor kinases (GRKs) are a family of serine/threonine protein kinases that specifically recognize agonist… (More)
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