Fumarate Hydratase

Known as: Fumarate Hydratase [Chemical/Ingredient], Fumarase, Hydratase, Fumarate 
An enzyme that catalyzes the reversible hydration of fumaric acid to yield L-malic acid. It is one of the citric acid cycle enzymes. EC 4.2.1.2.
National Institutes of Health

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Highly Cited
2016
Highly Cited
2016
Mutations of the tricarboxylic acid cycle enzyme fumarate hydratase cause hereditary leiomyomatosis and renal cell cancer… (More)
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2013
2013
The gene encoding the Krebs cycle enzyme fumarate hydratase (FH) is mutated in hereditary leiomyomatosis and renal cell cancer… (More)
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Highly Cited
2012
Highly Cited
2012
Two Krebs cycle genes, fumarate hydratase (FH) and succinate dehydrogenase (SDH), are mutated in a subset of human cancers… (More)
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Highly Cited
2011
Highly Cited
2011
Fumarate hydratase (FH) is an enzyme of the tricarboxylic acid cycle (TCA cycle) that catalyses the hydration of fumarate into… (More)
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Highly Cited
2011
Highly Cited
2011
Germline mutations in the FH gene encoding the Krebs cycle enzyme fumarate hydratase predispose to hereditary leiomyomatosis and… (More)
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Highly Cited
2009
Highly Cited
2009
Hereditary leiomyomatosis and renal cell cancer (HLRCC) is an inherited cancer syndrome linked to biallelic inactivation of the… (More)
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Highly Cited
2007
Highly Cited
2007
Fumarate hydratase (HGNC approved gene symbol – FH), also known as fumarase, is an enzyme of the tricarboxylic acid (TCA) cycle… (More)
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Review
2006
Review
2006
The phenomenon of enhanced glycolysis in tumours has been acknowledged for decades, but biochemical evidence to explain it is… (More)
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2006
2006
Defects in mitochondrial enzymes predispose to severe developmental defects as well as tumorigenesis. Heterozygous germline… (More)
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Highly Cited
2005
Highly Cited
2005
Several mitochondrial proteins are tumor suppressors. These include succinate dehydrogenase (SDH) and fumarate hydratase, both… (More)
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