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Purpose: Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors in combination with endocrine-therapy have emerged as an important… Expand The sigma-2 (σ2) receptor has been validated as a biomarker of the proliferative status of solid tumors. Therefore, radiotracers… Expand INTRODUCTION
Nine novel analogues were synthesized including a 6-carbon spacer analogue of ISO-1 (7). They have moderate binding… Expand Sigma receptors (sigma-1 and sigma-2) represent two independent classes of proteins. Their endogenous ligands may include the… Expand The sigma-2 receptor is expressed in higher density in proliferating (P) tumor cells versus quiescent (Q) tumor cells, thus… Expand CTRC-AACR San Antonio Breast Cancer Symposium: 2008 Abstracts
Background: We evaluated the use of high… Expand