FAQ

First in Human

Known as: firstInHuman 
The first time an active substance or agent is administered to a human during a study.
National Institutes of Health

Topic mentions per year

Topic mentions per year

2008-2017
01220082017

Papers overview

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2017
2017
Accelerating patient access to novel biologics using stable pool-derived product for non-clinical studies and single clone-derived product for clinical studies.
Cell cloning and subsequent process development activities are on the critical path directly impacting the timeline for… (More)
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2017
2017
The evolution of drug design at Merck Research Laboratories
On October 5, 1981, Fortune magazine published a cover article entitled the "Next Industrial Revolution: Designing Drugs by… (More)
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2016
2016
Adding value through accelerator mass spectrometry-enabled first in human studies.
Accelerator mass spectrometry (AMS) is an ultra-sensitive technique for the analysis of radiocarbon. It is applicable to… (More)
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2016
2016
Implantation of Autologous Selected Renal Cells in Diabetic Chronic Kidney Disease Stages 3 and 4—Clinical Experience of a “First in Human” Study
Introduction Animal models of chronic kidney disease demonstrate that a redundant population of therapeutically bioactive… (More)
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2015
2015
First in human nanotechnology doxorubicin delivery system to target epidermal growth factor receptors in recurrent glioblastoma.
There are limited treatment options for patients with recurrent glioblastoma (GBM). The EnGeneIC delivery vehicle (EDV) is a… (More)
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2015
2015
2-Year Follow-Up of the First in Human Transapical Implantation of Transcatheter Inverted Aortic Valve to Treat Native Mitral Valve Stenosis.
 
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Review
2008
Review
2008
Use of ex vivo systems for biomarker discovery.
Patients exhibit a range of responses to drug treatment owing to individual genetic variation and biology. A deeper understanding… (More)
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