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First in Human
Known as:
firstInHuman
The first time an active substance or agent is administered to a human during a study.
National Institutes of Health
Topic mentions per year
Topic mentions per year
2008-2017
0
1
2
2008
2017
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Accelerating patient access to novel biologics using stable pool-derived product for non-clinical studies and single clone-derived product for clinical studies.
Trent P Munro
,
Kim Le
,
+6 authors
Chetan T. Goudar
Biotechnology progress
2017
Cell cloning and subsequent process development activities are on the critical path directly impacting the timeline for…
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2017
2017
The evolution of drug design at Merck Research Laboratories
Frank K. Brown
,
Edward C. Sherer
,
Scott A. Johnson
,
M. Katharine Holloway
,
Bradley Sherborne
Journal of Computer-Aided Molecular Design
2017
On October 5, 1981, Fortune magazine published a cover article entitled the "Next Industrial Revolution: Designing Drugs by…
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2016
2016
Adding value through accelerator mass spectrometry-enabled first in human studies.
Mark A Seymour
Journal of labelled compounds…
2016
Accelerator mass spectrometry (AMS) is an ultra-sensitive technique for the analysis of radiocarbon. It is applicable to…
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2016
2016
Implantation of Autologous Selected Renal Cells in Diabetic Chronic Kidney Disease Stages 3 and 4—Clinical Experience of a “First in Human” Study
P. Peter Stenvinkel
,
Jonas Wadström
,
+5 authors
Torbjörn Lundgren
Kidney international reports
2016
Introduction Animal models of chronic kidney disease demonstrate that a redundant population of therapeutically bioactive…
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2015
2015
First in human nanotechnology doxorubicin delivery system to target epidermal growth factor receptors in recurrent glioblastoma.
James R Whittle
,
Jason D. Lickliter
,
+6 authors
Mark Andrew Rosenthal
Journal of clinical neuroscience : official…
2015
There are limited treatment options for patients with recurrent glioblastoma (GBM). The EnGeneIC delivery vehicle (EDV) is a…
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2015
2015
2-Year Follow-Up of the First in Human Transapical Implantation of Transcatheter Inverted Aortic Valve to Treat Native Mitral Valve Stenosis.
Vaikom S Mahadevan
,
Imthiaz Manoly
,
Ragheb Ir Hasan
JACC. Cardiovascular interventions
2015
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Review
2008
Review
2008
Use of ex vivo systems for biomarker discovery.
Edward R Lavallie
,
Andrew J. Dorner
,
Michael E Ransom Burczynski
Current opinion in pharmacology
2008
Patients exhibit a range of responses to drug treatment owing to individual genetic variation and biology. A deeper understanding…
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