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Fibroblast Growth Factor Receptor 2b

Known as: FGFR2b, Fibroblast Growth Factor Receptors 2b, Receptor, Fibroblast Growth Factor 2b 
An isoform of fibroblast growth factor receptor 2 found mainly in EPITHELIAL CELLS that is activated by FIBROBLAST GROWTH FACTOR 7 and FIBROBLAST… 
National Institutes of Health

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Fibroblast Growth Factor Receptor 2

Papers overview

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2019
2019
Effect of attenuation of fibroblast growth factor receptor 2b signaling on odontoblast differentiation and dentin formation
Attenuation of fibroblast growth factor receptor (FGFR) 2b signaling suppresses the differentiation of oral epithelial stem cells… 
2019
2019
Phase I results from the phase 1/3 FIGHT study evaluating bemarituzumab and mFOLFOX6 in advanced gastric/GEJ cancer (GC).
91 Background: GC with FGFR2b overexpression or FGFR2 amplification is associated with a poor prognosis. Bemarituzumab (bema… 
2017
2017
Updated antitumor activity and safety of FPA144, an ADCC-enhanced, FGFR2b isoform-specific monoclonal antibody, in patients with FGFR2b+ gastric cancer.
4067Background: FGFR2b-overexpressing gastric cancer is characterized by poor prognosis. FPA144, a humanized monoclonal IgG1… 
2016
2016
Antitumor activity and safety of FPA144, an ADCC-enhanced, FGFR2b isoform-selective monoclonal antibody, in patients with FGFR2b+ gastric cancer and advanced solid tumors.
2502Background: FGFR2b-overexpressing gastric cancer is a distinct setting with poor prognosis. FPA144, a humanized monoclonal… 
2016
2016
Buttressing a balanced brain: Target-derived FGF signaling regulates excitatory/inhibitory tone and adult neurogenesis within the maturating hippocampal network
ABSTRACT Brain development involves multiple levels of molecular coordination in forming a functional nervous system. The… 
2014
2014
Expression and purification of the recombinant kinase domain of FGFR2b and study of its structural change due to the interaction with gallic acid
Review
2013
Review
2013
Recent developments in palifermin basic, pre-clinical and clinical research
Keratinocyte growth factor (KGF or FGF7) was originally identified as an epithelial-specific mitogen of mesenchymal origin [1… 
2011
2011
Reciprocal interactions of Fgf10/Fgfr2b modulate the mouse tongue epithelial differentiation
The molecular mechanisms for epithelial differentiation have been studied by observing skin development in embryogenesis, but the… 
2010
2010
Supportive Treatments for Oncology Patients: Not Just Icing on the Cake
In this issue, Vadhan-Raj and colleagues describe the effects of palifermin on mucositis in patients receiving intensive… 
Review
2008
Review
2008
Studies of genes in the FGF signaling pathway and oral clefts with or without dental anomalies
To the Editor: Orofacial clefts comprise a large fraction of all human birth defects, affecting approximately one in every 500… 
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