Fibroblast Growth Factor Receptor 2 Isoform IIIb

Known as: FGFR-2 IIIb, FGFR2IIIb, FGFR2 IIIb 
An isoform of fibroblast growth factor receptor 2 where alternative splicing leads to the expression of the IIIb exon encoding the second half of the… (More)
National Institutes of Health

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Cell Differentiation processCell ProliferationCell Proliferation Regulatory ProcessEnzyme Gene
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Fibroblast Growth Factor Receptor 2

Papers overview

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2008
2008
Involvement of fibroblast growth factor receptor 2 isoform switching in mammary oncogenesis.
We identified the IIIb C2 epithelial cell-specific splice variant of fibroblast growth factor receptor 2 (FGFR2 IIIb C2) receptor… (More)
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Highly Cited
2007
Highly Cited
2007
Selective over-expression of fibroblast growth factor receptors 1 and 4 in clinical prostate cancer.
Fibroblast growth factor receptors (FGFRs) mediate the tumourigenic effects of FGFs in prostate cancer. These receptors are… (More)
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2007
2007
Epigenetic silencing through DNA and histone methylation of fibroblast growth factor receptor 2 in neoplastic pituitary cells.
Four members of the fibroblast growth factor receptor (FGFR) family of tyrosine kinases transduce signals of a diverse group of… (More)
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Highly Cited
2003
Highly Cited
2003
A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning.
To understand the role Fgf signalling in skin and hair follicle development, we analysed the phenotype of mice deficient for… (More)
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Highly Cited
2002
Highly Cited
2002
Regulation of thymic epithelium by keratinocyte growth factor.
Here we demonstrate that keratinocyte growth factor (KGF) and FGFR2IIIb signaling can affect development and function of thymic… (More)
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Highly Cited
2001
Highly Cited
2001
Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx1, or Bmp4.
Mice deficient for FgfR2-IIIb were generated by placing translational stop codons and an IRES-LacZ cassette into exon IIIb of… (More)
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Highly Cited
1999
Highly Cited
1999
Tumour suppressive properties of fibroblast growth factor receptor 2-IIIb in human bladder cancer
FGFRs (fibroblast growth factor receptors) are encoded by four genes (FGFR1 – 4). Alternative splicing results in various… (More)
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Highly Cited
1999
Highly Cited
1999
Characterization of fibroblast growth factor receptor 2 overexpression in the human breast cancer cell line SUM-52PE
The fibroblast growth factor receptor (FGFR)2 gene has been shown to be amplified in 5-10% of breast cancer patients. A breast… (More)
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1998
1998
Inhibition of growth of malignant rat prostate tumor cells by restoration of fibroblast growth factor receptor 2.
A loss of expression of fibroblast growth factor (FGF) receptor 2 IIIb (FGFR2IIIb), which responds to stroma-derived FGF… (More)
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Highly Cited
1997
Highly Cited
1997
Fibroblast growth factor receptor 2 limits and receptor 1 accelerates tumorigenicity of prostate epithelial cells.
Progressive loss of the differentiated phenotype and communication with stroma accompanies the transition of nonmalignant rat… (More)
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