Fas-Associated Death Domain Protein

Known as: Mediator of Receptor-Induced Toxicity, Fas Associating Protein with Death Domain, FADD Protein, Fas Associating 
A signal-transducing adaptor protein that associates with TNF RECEPTOR complexes. It contains a death effector domain that can interact with death… (More)

Topic mentions per year

Topic mentions per year

1995-2017
05019952017

Papers overview

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Highly Cited
2009
Highly Cited
2009
The death inducing signalling complex (DISC) formed by Fas receptor, FADD (Fas-associated death domain protein) and caspase 8 is… (More)
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2005
2005
Although evasion of apoptosis is thought to be required for the development of cancer, it is unclear which cell death pathways… (More)
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2004
2004
Two general pathways for cell death have been defined, apoptosis and necrosis. Previous studies in Jurkat cells have demonstrated… (More)
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Highly Cited
1999
Highly Cited
1999
Trimerization of the Fas receptor (CD95, APO-1), a membrane bound protein, triggers cell death by apoptosis. The main death… (More)
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Highly Cited
1998
Highly Cited
1998
Fas and Fas-associated death domain (FADD) play a critical role in the homeostasis of different cell types. The regulation of Fas… (More)
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Highly Cited
1997
Highly Cited
1997
The widely expressed protein Fas is a member of the tumour necrosis factor receptor family which can trigger apoptosis. However… (More)
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Highly Cited
1997
Highly Cited
1997
Upon activation, the apoptosis-inducing cell membrane receptor CD95 (APO-1/Fas) recruits a set of intracellular signaling… (More)
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Highly Cited
1996
Highly Cited
1996
To identify CAP3 and CAP4, components of the CD95 (Fas/APO-1) death-inducing signaling complex, we utilized nano-electrospray… (More)
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Highly Cited
1996
Highly Cited
1996
Fas/APO-1 and p55 tumor necrosis factor (TNF) receptor (p55-R) activate cellular mechanisms that result in cell death. Upon… (More)
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Highly Cited
1995
Highly Cited
1995
Using the cytoplasmic domain of Fas in the yeast two-hybrid system, we have identified a novel interacting protein, FADD, which… (More)
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