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Fas-Associated Death Domain Protein

Known as: Mediator of Receptor-Induced Toxicity, Fas Associating Protein with Death Domain, FADD Protein, Fas Associating 
A signal-transducing adaptor protein that associates with TNF RECEPTOR complexes. It contains a death effector domain that can interact with death… 
National Institutes of Health

Related topics

Related topics

26 relations
Adaptor Signaling Protein GeneApoptosisDAXX protein, humanDR3 and DR4/5 Mediated Apoptosis Pathway

Broader (1)

Proteins

Papers overview

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Highly Cited
2004
Highly Cited
2004
Direct Binding of Fas-associated Death Domain (FADD) to the Tumor Necrosis Factor-related Apoptosis-inducing Ligand Receptor DR5 Is Regulated by the Death Effector Domain of FADD*
Members of the tumor necrosis factor superfamily of receptors induce apoptosis by recruiting adaptor molecules through death… 
Highly Cited
2003
Highly Cited
2003
Apoptosis by leukemia cell-targeted diphtheria toxin occurs via receptor-independent activation of Fas-associated death domain protein.
PURPOSE We examined the mechanism of action of a targeted fusion toxin consisting of diphtheria toxin fused to granulocyte… 
Review
2003
Review
2003
Bile acid regulation of hepatic physiology: IV. Bile acids and death receptors.
  • H. HiguchiG. Gores
  • American Journal of Physiology - Gastrointestinal…
  • 2003
  • Corpus ID: 32116167
Toxic bile acids facilitate Fas and tumor necrosis factor-associated apoptosis-inducing ligand (TRAIL) death-receptor… 
Review
2002
Review
2002
Apoptotic signaling pathways: caspases and stress-activated protein kinases.
Apoptotic cell death is an active process mediated by various signaling pathways, which include the caspase cascade and the… 
Highly Cited
2002
Highly Cited
2002
Paclitaxel triggers cell death primarily via caspase-independent routes in the non-small cell lung cancer cell line NCI-H460.
PURPOSE Here we report on the role of mitochondria, death receptors (DRs), and caspases in exerting the cytotoxic effect of… 
Highly Cited
2001
Highly Cited
2001
Non-apoptotic Signaling Pathways Activated by Soluble Fas Ligand in Serum-starved Human Fibroblasts
Many Fas-expressing cells do not undergo cell death upon Fas stimulation. In the normal human diploid cell line GM6112, the… 
Highly Cited
2000
Highly Cited
2000
A Dominant Negative Fas-associated Death Domain Protein Mutant Inhibits Proliferation and Leads to Impaired Calcium Mobilization in Both T-cells and Fibroblasts*
Death domain-containing members of the tumor necrosis factor (TNF) receptor family (“death receptors”) can induce apoptosis upon… 
Highly Cited
1997
Highly Cited
1997
FLAME-1, a Novel FADD-like Anti-apoptotic Molecule That Regulates Fas/TNFR1-induced Apoptosis*
We identified and cloned a novel human protein that contains FADD/Mort1 death effector domain homology regions, designated FLAME… 
Review
1997
Review
1997
Portrait of an executioner: the molecular mechanism of FAS/APO-1-induced apoptosis.
Fas/APO-1 is a member of the TNF receptor family and plays a dominant role in the immune system, down-regulating the immune… 
Highly Cited
1995
Highly Cited
1995
TCR/CD3 coupling to Fas-based cytotoxicity
We studied the coupling of the TCR/CD3 complex to a T cell effector function, namely Fas-based T-cell-mediated cytotoxicity… 
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