Semantic Scholar uses AI to extract papers important to this topic.
Frontotemporal dementia is a clinically and pathologically heterogeneous group of neurodegenerative disorders, with progressive… Expand As dementia is a fast-growing health care problem, it is becoming an increasingly urgent need to provide an early diagnosis in… Expand 25% of all people aged 55 years and older have a family history of dementia. For most, the family history is due to genetically… Expand Pathogenic mutations in the three known genes – the amyloid precursor protein (APP), presenilin 1 (PSEN1), presenilin 2 (PSEN2… Expand Pyroglutamic acid or 5-oxoproline is the cyclic lactam of glutamic acid. Its presence in living cells has been reported from… Expand Although the key pathologies of the demented brain have been known for over a century, and the senile plaque is the focus of… Expand BACKGROUND
The aggregation of specific proteins is a common feature of the familial dementias, but whether the formation of… Expand Aberrant protein processing with tissue deposition is associated with many common neurodegenerative disorders; however, the… Expand Inherited forms of prion diseases are associated with mutations in the prion protein gene. A common polymorphism at codon 129 is… Expand The polymerase chain reaction was used to screen DNA samples from 12 unrelated individuals with various familial dementias and… Expand