Familial Cerebral Amyloid Angiopathy

The E693Q mutation in the amyloid beta precursor protein (APP) leads to cerebral amyloid angiopathy (CAA), with recurrent… Expand

: Amyloid beta protein (A beta) deposition in the cerebral arterial and capillary walls is one of the major characteristics of… Expand

Cerebrovascular amyloid beta-protein (Abeta) deposition is a pathological feature of several related disorders including… Expand

We have studied the effects of amyloid β-peptide analogues on the activity of tissue-type plasminogen activator (t-PA) in vitro… Expand

Deposition of extraneuronal fibrils that assemble from the 39-43 residue beta/A4 amyloid protein is one of the earliest… Expand

beta-Amyloid (A beta) deposition in fibril form is the central event in a number of diseases, including Alzheimer's disease (AD… Expand

Human hereditary cerebral hemorrhage with amyloidosis of the Dutch type (HCHWA-D), an autosomal dominant form of cerebral amyloid… Expand

Two families have been described previously with the features of an autosomal dominant familial cerebral amyloid angiopathy with… Expand

Amyloid deposition is a prominent feature of a number of brain disorders, in which amyloid fibrils are found within blood vessel… Expand

Eleven patients belonging to two generations of a Dutch family with cerebral and cerebellar haemorrhage, haemorrhagic infarction… Expand