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Familial Cerebral Amyloid Angiopathy

Known as: Cerebral Amyloid Angiopathy, Familial, Autosomal Dominant Cerebrovascular Amyloidosis, HCHWA 
A familial disorder marked by AMYLOID deposits in the walls of small and medium sized blood vessels of CEREBRAL CORTEX and MENINGES.
National Institutes of Health

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Cerebral Amyloid Angiopathy, HereditaryDementia, familial BritishHereditary Cerebral Amyloid Angiopathy, Icelandic Type
In BloodMicrobiologicalchemically inducednursing therapy
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Papers overview

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Highly Cited
2004
Highly Cited
2004
Aβ is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis
The E693Q mutation in the amyloid beta precursor protein (APP) leads to cerebral amyloid angiopathy (CAA), with recurrent… 
Highly Cited
1997
Highly Cited
1997
Rapid Degeneration of Cultured Human Brain Pericytes by Amyloid β Protein
Abstract: Amyloid β protein (Aβ) deposition in the cerebral arterial and capillary walls is one of the major characteristics of… 
Highly Cited
1996
Highly Cited
1996
Enhanced pathologic properties of Dutch-type mutant amyloid beta-protein.
Cerebrovascular amyloid beta-protein (Abeta) deposition is a pathological feature of several related disorders including… 
Review
1995
Review
1995
Role of the β‐amyloid protein in Alzheimer's disease
A major histopathological hallmark of Alzheimer's disease (AD) is the presence of amyloid deposits in the parenchyma of the… 
Highly Cited
1992
Highly Cited
1992
Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid beta-protein.
Deposition of extraneuronal fibrils that assemble from the 39-43 residue beta/A4 amyloid protein is one of the earliest… 
Highly Cited
1991
Highly Cited
1991
Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation.
Highly Cited
1990
Highly Cited
1990
Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch).
Human hereditary cerebral hemorrhage with amyloidosis of the Dutch type (HCHWA-D), an autosomal dominant form of cerebral amyloid… 
Highly Cited
1990
Highly Cited
1990
Familial cerebral amyloid angiopathy with nonneuritic amyloid plaque formation.
Two families have been described previously with the features of an autosomal dominant familial cerebral amyloid angiopathy with… 
Highly Cited
1990
Highly Cited
1990
Coexistence of Alzheimer's amyloid precursor protein and amyloid protein in cerebral vessel walls.
Polyclonal antibodies to synthetic peptides homologous to amino acid residues 45-62, 597-624, and 676-695 of the predicted… 
Highly Cited
1987
Highly Cited
1987
Brain amyloid in normal aging and cerebral amyloid angiopathy is antigenically related to Alzheimer's disease beta-protein.
Amyloid deposition is a prominent feature of a number of brain disorders, in which amyloid fibrils are found within blood vessel… 
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