Factor VIIIa

Known as: VIIIa, Coagulation Factor, Factor VIII, Thrombin-Activated, Factor VIIIa [Chemical/Ingredient] 
Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved by thrombin to form factor VIIIa. Factor VIIIa exists as a non… (More)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Factor VIII is a procofactor that plays a critical role in blood coagulation, and is missing or defective in hemophilia A. We… (More)
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1998
1998
Factor VIIIa, the protein cofactor for factor IXa, is comprised of A1, A2, and A3-C1-C2 subunits. Isolated subunits of factor… (More)
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1997
1997
The protein cofactor, factor (F) VIIIa, is required for the efficient conversion of the substrate FX to FXa by the serine… (More)
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Highly Cited
1994
Highly Cited
1994
Inherited resistance to activated protein C (APC) is a recently identified major cause of thrombosis. It is associated with a… (More)
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1994
1994
Factor VIIIa is a non-covalent heterotrimer of A1, A2, and A3-C1-C2 subunits. Previously, we speculated that the central portion… (More)
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1994
1994
Factor VIIIa is inactivated by both factor IXa and activated protein C. The latter protease rapidly attacked a site at Arg562 (A2… (More)
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1993
1993
Platelet activation leads to the incorporation of 32[PO4(2-)] into bovine coagulation factor Va and recombinant human factor VIII… (More)
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1992
1992
The activation of factor X by factor IXa (fIXa) in the presence of phosphatidylcholine-phosphatidylserine (PCPS) vesicles is… (More)
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Highly Cited
1991
Highly Cited
1991
Human factor VIII and factor VIIIa were proteolytically inactivated by activated protein C. Cleavages occurred within the heavy… (More)
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1988
1988
Proteolytic activation of human Factor VIII (VIIIa) by thrombin was correlated with the generation of a light-chain-derived 73(71… (More)
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