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Factor VIIIa

Known as: VIIIa, Coagulation Factor, Factor VIII, Thrombin-Activated, Factor VIIIa [Chemical/Ingredient] 
Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved by thrombin to form factor VIIIa. Factor VIIIa exists as a non… Expand
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Factor VIII is a procofactor that plays a critical role in blood coagulation, and is missing or defective in hemophilia A. We… Expand
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Highly Cited
1997
Highly Cited
1997
The protein cofactor, factor (F) VIIIa, is required for the efficient conversion of the substrate FX to FXa by the serine… Expand
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Highly Cited
1996
Highly Cited
1996
Factor IXa, a serine protease of blood coagulation, functions at least 100,000 times more efficiently when bound to factor VIIIa… Expand
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Highly Cited
1994
Highly Cited
1994
Inherited resistance to activated protein C (APC) is a recently identified major cause of thrombosis. It is associated with a… Expand
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Highly Cited
1994
Highly Cited
1994
Factor VIIIa is inactivated by both factor IXa and activated protein C. The latter protease rapidly attacked a site at Arg562 (A2… Expand
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Highly Cited
1994
Highly Cited
1994
Factor VIIIa is a non-covalent heterotrimer of A1, A2, and A3-C1-C2 subunits. Previously, we speculated that the central portion… Expand
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Highly Cited
1993
Highly Cited
1993
Publisher Summary This chapter focuses on the role of factor VIII and factor VIIIa present in blood. The factor VIIIa apparently… Expand
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Highly Cited
1991
Highly Cited
1991
Heterodimeric human factor VIII was proteolytically activated by catalytic levels of thrombin to yield the (labile) active… Expand
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Highly Cited
1991
Highly Cited
1991
Human factor VIII and factor VIIIa were proteolytically inactivated by activated protein C. Cleavages occurred within the heavy… Expand
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Highly Cited
1981
Highly Cited
1981
The kinetic parameters of bovine factor X activation by bovine factor IXa have been determined in the absence and presence of Ca2… Expand
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