Factor VII-targeting Immunoconjugate Protein ICON-1

Known as: ICON-1, FVII Modified Conjugate ICON-1, VII-Fc Fusion Protein ICON-1 
A human immunoconjugate (ICON) fusion protein composed of a modified version of human factor VII (FVII) which targets tissue factor (TF) that is… (More)
National Institutes of Health

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Topic mentions per year

1994-2016
02419942016

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2017
2017
Targeting cancer stem cell (CSC) represents a promising therapeutic approach as it can potentially fight cancer at its root. The… (More)
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2016
2016
BACKGROUND As a consequence of population ageing, the number of older patients presenting with acute coronary syndrome (ACS) is… (More)
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2011
2011
Background:The purpose of this study was to test a novel, dual tumour vascular endothelial cell (VEC)- and tumour cell-targeting… (More)
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2011
2011
Lung cancer is the leading cause of cancer death. Conventional photodynamic therapy (PDT) using a nontargeted photosensitizer… (More)
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2011
2011
Congenital factor VII (FVII) deficiency is a rare autosomal recessive bleeding disorder. Its clinical manifestation and… (More)
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2010
2010
The cell surface receptor tissue factor (TF) is regarded as a common but specific target on angiogenic tumor vascular endothelial… (More)
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2009
2009
The objective of this study was to develop a ligand-targeted photodynamic therapy (tPDT) by conjugating factor VII (fVII) protein… (More)
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2002
2002
Activated Factor VII (FVIIa) is a vitamin-K-dependent serine protease that initiates blood clotting after interacting with its… (More)
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1998
1998
Murine monoclonal antibodies (designated hVII-B101/B1, hVII-DC2/D4 and hVII-DC6/3D8) directed against human factor VII (FVII… (More)
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1994
1994
The blood coagulation cascade is initiated when vessel injury allows factor VII (FVII) to form a complex with tissue factor (TF… (More)
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