FAQ

FUS/DDIT3 Fusion Gene

Known as: FUS/CHOP FUSION GENE, FUS-CHOP Fusion Gene, FUS-DDIT3 Fusion Gene 
A fusion gene that results from a chromosomal translocation t(12;16)(q13;p11) which fuses either the first 5, 7 or 8 exons of the FUS gene with exon… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1993-2016
02419932016

Related topics

Related topics

1 relation
Myxoid/Round Cell Liposarcoma

Related mentions per year

Related mentions per year

1993-2018
1990200020102020
FUS/DDIT3 Fusion Gene
Myxoid/Round Cell Liposarcoma

Papers overview

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Highly Cited
2006
Highly Cited
2006
Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma.
A subset of sarcomas is associated with specific chromosomal translocations that give rise to fusion genes believed to… (More)
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Highly Cited
2001
Highly Cited
2001
Prognostic impact of P53 status, TLS-CHOP fusion transcript structure, and histological grade in myxoid liposarcoma: a molecular and clinicopathologic study of 82 cases.
PURPOSE A specific TLS-CHOP fusion gene resulting from the t(12;16) is present in at least 95% of myxoid liposarcomas (MLS… (More)
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2000
2000
The chimeric FUS/TLS-CHOP fusion protein specifically induces liposarcomas in transgenic mice
The characteristic t(12;16)(q13;p11) chromosomal translocation, which leads to gene fusion that encodes the FUS-CHOP chimeric… (More)
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2000
2000
Monoclonality of multifocal myxoid liposarcoma: confirmation by analysis of TLS-CHOP or EWS-CHOP rearrangements.
Multifocal presentation, defined as the presence of tumor at two or more anatomically separate sites, before the manifestation of… (More)
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2000
2000
Specificity of TLS-CHOP rearrangement for classic myxoid/round cell liposarcoma: absence in predominantly myxoid well-differentiated liposarcomas.
Myxoid liposarcoma (LS), the most common subtype of LS, is known to be characterized by the specific t(12;16) resulting in a TLS… (More)
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Highly Cited
1996
Highly Cited
1996
Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element.
CHOP (GADD153) is a mammalian nuclear protein that dimerizes with members of the C/EBP family of transcriptional factors. Absent… (More)
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1995
1995
Translocation t(12;16)(q13;p11) in myxoid liposarcoma and round cell liposarcoma: molecular and cytogenetic analysis.
Translocation t(12;16)(q13;p11) is regarded as a diagnostic marker for myxoid liposarcoma. Cytogenetic data on round cell… (More)
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Highly Cited
1994
Highly Cited
1994
A novel effector domain from the RNA-binding protein TLS or EWS is required for oncogenic transformation by CHOP.
In human myxoid liposarcoma, a chromosomal rearrangement leads to fusion of the growth-arresting and DNA-damage-inducible… (More)
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Highly Cited
1994
Highly Cited
1994
CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest.
The growth arrest and DNA damage-inducible gene CHOP (GADD153) encodes a small nuclear protein from the C/EBP family, originally… (More)
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Highly Cited
1993
Highly Cited
1993
Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma.
Human myxoid liposarcomas contain a characteristic chromosomal translocation, t(12;16)(q13;p11), that is associated with a… (More)
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