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FRAP1 protein, human

Known as: RAFT1 protein, human, FKBP12-Rapamycin Complex-Associated Protein, FKBP-Rapamycin Associated Protein 
A protein that helps control several cell functions, including cell division and survival, and binds to rapamycin and other drugs. Mammalian target… 
National Institutes of Health

Related topics

Related topics

27 relations
Adipocytokine Signaling PathwayCTCF PathwayCell Proliferation Regulatory ProcessEF-1 Peptide

Broader (2)

FKBP12-rapamycin associated proteinProtein-Serine-Threonine Kinases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis
The nuclear translocation of a transcription factor that promotes lysosomal biogenesis is inhibited when lysosomal function is… 
Highly Cited
2011
Highly Cited
2011
The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
A search for substrates of a growth-promoting kinase revealed a regulatory feedback loop involved in tumor suppression. The… 
Review
2010
Review
2010
Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress.
Highly Cited
2008
Highly Cited
2008
p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling
Highly Cited
2006
Highly Cited
2006
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.
Highly Cited
2004
Highly Cited
2004
Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton
Highly Cited
2004
Highly Cited
2004
The LKB1 tumor suppressor negatively regulates mTOR signaling.
Highly Cited
2003
Highly Cited
2003
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.
Tuberous sclerosis complex (TSC) is a genetic disease caused by mutation in either TSC1 or TSC2. The TSC1 and TSC2 gene products… 
Highly Cited
2002
Highly Cited
2002
mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery
Highly Cited
2001
Highly Cited
2001
Mammalian TOR: A Homeostatic ATP Sensor
The bacterial macrolide rapamycin is an efficacious anticancer agent against solid tumors. In a hypoxic environment, the increase… 
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