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FR 901464

Known as: FR-901464, FR901464 
National Institutes of Health

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2 relations

Broader (2)

PyransSpiro Compounds

Papers overview

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2016
2016
Abstract 3013: Identification of PHF5A as a common cellular target of splicing-modulating chemical probes
Recent discoveries that splicing factors such SF3B1, U2AF1, SRSF2 are frequently mutated in multiple hematological malignancies… 
2012
2012
SYNTHETIC AND BIOLOGICAL STUDIES ON ANALOGUES OF FR901464 AND TMC-205
FR901464 is a natural product that elicits anticancer activity via inhibition of pre-mRNA splicing, a novel therapeutic approach… 
2010
2010
SYNTHETIC, CHEMICAL AND BIOLOGICAL STUDIES OF FR901464 ANALOGUES
Since the total synthesis of FR901464 was achieved in our group, its structure-activity relationships were extensively studied… 
2010
2010
STUDIES DIRECTED TOWARDS THE TOTAL SYNTHESIS OF FR-901464 AND DEVLOPMENT OF NOVEL SYNTHETIC METHODOLOGIES
2008
2008
SYNTHETIC, CHEMICAL, AND BIOLOGICAL STUDIES OF FR901464 AND STUDIES OF THE SILVER AND ZIRCONIUM PROMOTED ALKYNYL ADDITION REACTION
The total synthesis of FR901464 was accomplished in at total of 29 steps, which is the shortest synthesis to date. Degradation… 
2007
2007
Studies on the mode of action of FR901464 that inhibits pre-mRNA processing in fission yeast
2007
2007
Therapeutics: Promoting a mixed message
10.1038/nrc2218 mRNA splicing is not necessarily a target that leaps to mind when considering new treatments for cancer. But two…