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FP-1039

Known as: FGF Receptor Antagonist HGS1036, GSK3052230, HGS1036 
A soluble fusion protein consisting of the extracellular domain of human fibroblast growth factor receptor 1 (FGFR1) fused to the Fc portion of human… Expand
National Institutes of Health

Papers overview

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2019
2019
OBJECTIVES GSK3052230 (FP-1039) is a soluble fusion protein that acts as ligand trap sequestering fibroblast growth factors (FGFs… Expand
Highly Cited
2016
Highly Cited
2016
BACKGROUND Fibroblast growth factors (FGFs) play important roles in multiple cancers by supporting tumor growth and angiogenesis… Expand
2016
2016
Fibroblast growth factor (FGF) ligand-dependent signaling has a fundamental role in cancer development and tumor maintenance… Expand
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2014
2014
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Fibroblast growth factor (FGF) ligand-dependent signaling… Expand
Highly Cited
2013
Highly Cited
2013
A soluble FGF receptor trap effectively inhibits tumor growth in the absence of toxicity. Treating Cancer by Design The… Expand
Highly Cited
2011
Highly Cited
2011
Purpose: We previously reported that a fibroblast growth factor (FGF) receptor (FGFR) signaling pathway drives growth of lung… Expand
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2010
2010
Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC Endometrial cancer is the most common… Expand
2010
2010
Figure 1. Targeting the FGF/FGFR Pathway with FP-1039. The FGF axis contains 4 FGF receptors with multiple splice forms and 22… Expand
2007
2007
B55 FP-1039 is a soluble fusion protein consisting of the extracellular domain of human fibroblast growth factor receptor 1c… Expand