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GSK3052230 (FP-1039) is a soluble fusion protein that acts as ligand trap sequestering fibroblast growth factors (FGFs… Expand BACKGROUND
Fibroblast growth factors (FGFs) play important roles in multiple cancers by supporting tumor growth and angiogenesis… Expand Fibroblast growth factor (FGF) ligand-dependent signaling has a fundamental role in cancer development and tumor maintenance… Expand Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA
Fibroblast growth factor (FGF) ligand-dependent signaling… Expand A soluble FGF receptor trap effectively inhibits tumor growth in the absence of toxicity. Treating Cancer by Design The… Expand Purpose: We previously reported that a fibroblast growth factor (FGF) receptor (FGFR) signaling pathway drives growth of lung… Expand Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC
Endometrial cancer is the most common… Expand Figure 1. Targeting the FGF/FGFR Pathway with FP-1039. The FGF axis contains 4 FGF receptors with multiple splice forms and 22… Expand B55 FP-1039 is a soluble fusion protein consisting of the extracellular domain of human fibroblast growth factor receptor 1c… Expand