FLT3 Internal Tandem Duplication

Known as: FLT3-ITD Mutation, FLT3/ITD Mutation 
A genetic abnormality that arises from duplications of the juxtamembrane portion of the gene and results in constitutive activation of the FLT3… (More)
National Institutes of Health

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Highly Cited
2010
Highly Cited
2010
PURPOSE To analyze the frequency and prognostic impact of isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2… (More)
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Highly Cited
2009
Highly Cited
2009
To evaluate internal tandem duplication (ITD) insertion sites and length as well as their clinical impact in younger adult… (More)
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Highly Cited
2008
Highly Cited
2008
An internal tandem duplication in the fms-like tyrosine kinase 3 gene (FLT3/ITD) is associated with poor prognosis in acute… (More)
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Highly Cited
2006
Highly Cited
2006
FLT3 internal tandem duplications (FLT3/ITDs) in the juxtamembrane domain are found in approximately 25% of acute myeloid… (More)
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Highly Cited
2005
Highly Cited
2005
Two distinct forms of fms-like tyrosine kinase (FLT3) gene aberrations, internal tandem duplication (ITD) and tyrosine kinase… (More)
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Highly Cited
2003
Highly Cited
2003
FLT3 is a receptor tyrosine kinase that is expressed on early hematopoietic progenitor cells and plays an important role in stem… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND AND OBJECTIVES Cytogenetics is the most important prognostic factor in acute myeloid leukemia (AML). However, a high… (More)
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Highly Cited
2002
Highly Cited
2002
FLT3 receptor tyrosine kinase is expressed on lymphoid and myeloid progenitors in the hematopoietic system. Activating mutations… (More)
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Highly Cited
2001
Highly Cited
2001
Internal tandem duplication (ITD) mutations of the receptor tyrosine kinase FLT3 have been found in 20% to 30% of patients with… (More)
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Highly Cited
2000
Highly Cited
2000
Genomic DNA from 106 cases of adult de novo acute myeloid leukaemia (AML) was screened by polymerase chain reaction (PCR) and gel… (More)
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