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FLICE Inhibitory Protein

Known as: Viral FLICE Protein, vFLIP, ORF71/K13 
FLICE inhibitory protein (188 aa, ~21 kDa) is encoded by the human HHV8 ORF71 gene. This protein is involved in the modulation of host signaling… 
National Institutes of Health

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Genes, ViralHHV8 ORF71 GeneNegative Regulation of ApoptosisSignal Transduction

Papers overview

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2019
2019
Inhibition of A20 deubiquitinase activity by KSHV vFLIP: A SUMO dependent mechanism?
KSHV vFLIP is a potent activator of NFκB signaling and an inhibitor of apoptosis and autophagy. Inhibition of vFLIP function and… 
2018
2018
Generation of a KSHV K13 deletion mutant for vFLIP function study
Kaposi's sarcoma‐associated herpesvirus (KSHV)‐encoded viral Fas‐associated death domain‐like IL‐1‐converting enzyme inhibitory… 
2017
2017
Structural and functional analysis of the Kaposi's sarcoma-associated herpesvirus vFLIP internal ribosome entry site
Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic virus, the etiological agent of Kaposi's sarcoma (KS) and primary… 
2015
2015
Mechanism of IKK activation by the Kaposi's sarcoma-associated herpesvirus protein vFLIP and its cellular homologues
Activation of the NF-κB pathway is linked to cancer development and progression. Kaposi’s sarcoma-associated herpesvirus (KSHV… 
2015
2015
Suppression of lytic replication of Kaposi’s sarcoma-associated herpesvirus by autophagy during initial infection in NIH 3T3 fibroblasts
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the infectious cause of the angioproliferative neoplasm Kaposi’s sarcoma (KS… 
2014
2014
The A20/Itch ubiquitin-editing complex is required for KSHV RTA-induced degradation of vFLIP
2013
2013
Role of IRF 4 in IFN-stimulated gene induction and maintenance of KSHV latency in primary effusion lymphoma cells
Interferon regulatory factor (IRF) 4 is a hematopoietic cell-specific transcription factor that regulates the maturation and… 
2013
2013
Cancer Therapy : Preclinical A Purine Scaffold HSP 90 Inhibitor BIIB 021 Has Selective Activity against KSHV-Associated Primary Effusion Lymphoma and Blocks vFLIP K 13-Induced NFk B
Purpose: Kaposi sarcoma–associated herpes virus (KSHV)–associated primary effusion lymphomas (PEL) have extremely poor prognosis… 
2010
2010
Lentiviral Vectors Encoding Influenza A Nucleprotein and vFLIP Induce Potent CD8 T-Cell Responses and Confer Protection Against Lethal Flu Challenge
2009
2009
Endothelial Cells in ORFK 13 / vFLIP Herpesvirus-Encoded Induced by Kaposi ' s Sarcoma-Associated Gene Regulation and Functional Alterations
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