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FKBP8 protein, human
Known as:
FK506-Binding Protein 8
, Rotamase
, FKBP38 protein, human
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Peptidyl-prolyl cis-trans isomerase FKBP8 (412 aa, ~45 kDa) is encoded by the human FKBP8 gene. This protein is involved in immunoregulation, protein…
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National Institutes of Health
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Related topics
Related topics
3 relations
Enzyme Gene
FKBP8 gene
Broader (1)
Tacrolimus Binding Proteins
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
Osteogenesis imperfecta due to mutations in non-collagenous genes: lessons in the biology of bone formation
J. Marini
,
A. Reich
,
S. Smith
Current opinion in pediatrics
2014
Corpus ID: 205832737
Purpose of review Osteogenesis imperfecta or ’brittle bone disease’ has mainly been considered a bone disorder caused by collagen…
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Review
2008
Review
2008
Ascomycin and FK506: Pharmacology and Therapeutic Potential as Anticonvulsants and Neuroprotectants
G. Sierra-Paredes
,
G. Sierra-marcuňo
CNS neuroscience & therapeutics
2008
Corpus ID: 205687803
Ascomycin and FK506 are powerful calcium‐dependent serine/threonine protein phosphatase (calcineurin [CaN], protein phosphatase…
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Review
2000
Review
2000
FK506, an immunosuppressant targeting calcineurin function.
F. Dumont
Current medicinal chemistry
2000
Corpus ID: 25221758
The macrolactam natural product, FK506 (Tacrolimus), acts as a powerful and clinically useful immnosuppressant through disruption…
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1998
1998
A maize FK506-sensitive immunophilin, mzFKBP-66, is a peptidylproline cis-trans-isomerase that interacts with calmodulin and a 36-kDa cytoplasmic protein
G. Hueros
,
J. Rahfeld
,
F. Salamini
,
Richard D. Thompson
Planta
1998
Corpus ID: 25455733
Abstract. A member of a eukaryotic gene superfamily, encoding a peptidylproline cis-trans-isomerase (rotamase) has been isolated…
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Highly Cited
1997
Highly Cited
1997
Structural and Functional Analysis of the Mitotic Rotamase Pin1 Suggests Substrate Recognition Is Phosphorylation Dependent
R. Ranganathan
,
K. Lu
,
T. Hunter
,
J. Noel
Cell
1997
Corpus ID: 16219532
Highly Cited
1994
Highly Cited
1994
Cloning and characterization of chloroplast and cytosolic forms of cyclophilin from Arabidopsis thaliana.
V. Lippuner
,
I. Chou
,
S. V. Scott
,
W. F. Ettinger
,
S. Theg
,
C. Gasser
The Journal of biological chemistry
1994
Corpus ID: 21505591
Highly Cited
1992
Highly Cited
1992
Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex.
P. Tai
,
M. Albers
,
H. Chang
,
L. E. Faber
,
S. Schreiber
Science
1992
Corpus ID: 38394621
Immunophilins, a family of proteins that exhibit rotamase (peptidyl-prolyl cis-trans isomerase) activity in vitro, are expressed…
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Highly Cited
1992
Highly Cited
1992
An immunophilin that binds M(r) 90,000 heat shock protein: main structural features of a mammalian p59 protein.
I. Callebaut
,
J. Renoir
,
+4 authors
J. Mornon
Proceedings of the National Academy of Sciences…
1992
Corpus ID: 38334811
In the rabbit, a p59 protein included in the untransformed, non-DNA binding, "8-9S," steroid receptor complexes binds heat shock…
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Highly Cited
1990
Highly Cited
1990
Structure and expression of cytosolic cyclophilin/peptidyl-prolyl cis-trans isomerase of higher plants and production of active tomato cyclophilin in Escherichia coli.
C. Gasser
,
D. Gunning
,
K. Budelier
,
S. Brown
Proceedings of the National Academy of Sciences…
1990
Corpus ID: 22059463
cDNA clones encoding proteins of approximately 18 kDa in which 83% of the amino acids are conserved relative to the published…
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Highly Cited
1990
Highly Cited
1990
Inhibition of FKBP rotamase activity by immunosuppressant FK506: twisted amide surrogate.
M. Rosen
,
R. Standaert
,
A. Galat
,
M. Nakatsuka
,
S. Schreiber
Science
1990
Corpus ID: 221331
The immunosuppressive agents cyclosporin A and FK506 inhibit the transcription of early T cell activation genes. The binding…
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