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FK 888

Known as: FK-888, FK888, L-Alaninamide, trans-4-hydroxy-1-((1-methyl-1H-indol-3-yl)carbonyl)-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)- 
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
We investigated the mechanisms underlying the pruritogenic response induced by trypsin in mice, to assess the relevance of… Expand
2002
2002
The lateral septal nucleus (LS) presents a dense plexus of fibers containing substance P (SP), which is known to induce… Expand
2002
2002
In certain skin diseases, stress can modulate the induction and/or progression of cutaneous manifestations. However, little is… Expand
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Highly Cited
1999
Highly Cited
1999
UNLABELLED Postoperative incident pain is not easily treated with opioids. Mechanical hyperalgesia induced by skin incision in… Expand
Highly Cited
1998
Highly Cited
1998
Residues in transmembrane domain (TM)-III, TM-V, TM-VI, and TM-VII believed to be facing the deep part of the presumed main… Expand
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Highly Cited
1997
Highly Cited
1997
The ability of tachykinin NK1 receptor antagonists to inhibit GR73632 (D-Ala-[L-Pro9,Me-Leu8]substance P-(7-11))-induced foot… Expand
Highly Cited
1997
Highly Cited
1997
Sodium-butyrate-pretreated and Con A-stimulated P815 mast cell line generated 3T3 fibroblast proliferating activity. This… Expand
1995
1995
1 This study investigates the effects of capsaicin‐induced depletion of sensory neuropeptides and of neurokinin! (NK1) receptor… Expand
Highly Cited
1993
Highly Cited
1993
1 We compared the effects of two novel tachykinin receptor antagonists, FK888 (selective at the tachykinin NK1 receptor) and… Expand
Highly Cited
1992
Highly Cited
1992
1 In our search for compounds that inhibit the binding of [3H]‐substance P (SP) to guinea‐pig lung membranes, the dipeptide SP… Expand