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FGFR4 Inhibitor H3B-6527

Known as: H3B 6527, H3B6527, H3B-6527 
An orally bioavailable inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
Fibroblast growth factor receptor 4 (FGFR4), a tyrosine kinase receptor for FGFs, is involved in diverse cellular processes… Expand
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Review
2019
Review
2019
  • R. Roskoski
  • Pharmacological research
  • 2019
  • Corpus ID: 208319124
The human fibroblast growth factor family consists of 22 factors and five transmembrane receptors. Of the 22 factors, eighteen… Expand
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2019
2019
4095Background: FGF19 overexpression is hypothesized to hyperactivate FGFR4 and its downstream signaling pathway leading to… Expand
2018
2018
PurposeThis Phase I study estimated the effect of a high-fat meal on the pharmacokinetics (PK) of H3B-6527, a covalent inhibitor… Expand
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2018
2018
The FGFR family can be activated by FGFs and plays important roles in regulating cell growth, differentiation, migration, and… Expand
2017
2017
Activation of the fibroblast growth factor receptor FGFR4 by FGF19 drives hepatocellular carcinoma (HCC), a disease with few, if… Expand
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2017
2017
Hepatocellular carcinoma (HCC) has limited treatment options and generally poor prognosis. Recent genomic studies have identified… Expand
2016
2016
Purpose The purpose of this study is to investigate the role of fibroblast growth factor receptor 4 (FGFR4) polymorphism in… Expand
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2010
2010
FGFR4 Arg388 genotype is associated with pathological complete response to neoadjuvant chemotherapy for primary breast cancer F… Expand
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2009
2009
The genotype analysis of the Gly and Arg allele at codon 388 of fibroblast growth factor receptor-4 (FGFR4) gene was evaluated… Expand