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FGFR4 Inhibitor H3B-6527

Known as: H3B 6527, H3B6527, H3B-6527 
An orally bioavailable inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration… Expand
National Institutes of Health

Papers overview

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2019
2019
4095Background: FGF19 overexpression is hypothesized to hyperactivate FGFR4 and its downstream signaling pathway leading to… Expand
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Review
2019
Review
2019
The human fibroblast growth factor family consists of 22 factors and five transmembrane receptors. Of the 22 factors, eighteen… Expand
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2019
2019
Abstract 1. H3B-6527 is an orally available covalent small molecule inhibitor of FGFR4 undergoing evaluation in adults with… Expand
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2019
2019
4121Background: FGFR4/FGF19 signaling axis is a novel therapeutic target in HCC. Multiple covalent FGFR4 inhibitors, including… Expand
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2018
2018
PurposeThis Phase I study estimated the effect of a high-fat meal on the pharmacokinetics (PK) of H3B-6527, a covalent inhibitor… Expand
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2017
2017
Activation of the fibroblast growth factor receptor FGFR4 by FGF19 drives hepatocellular carcinoma (HCC), a disease with few, if… Expand
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2017
2017
Hepatocellular carcinoma (HCC) has limited treatment options and generally poor prognosis. Recent genomic studies have identified… Expand
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2016
2016
Purpose The purpose of this study is to investigate the role of fibroblast growth factor receptor 4 (FGFR4) polymorphism in… Expand
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2010
2010
FGFR4 Arg388 genotype is associated with pathological complete response to neoadjuvant chemotherapy for primary breast cancer F… Expand
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2009
2009
The genotype analysis of the Gly and Arg allele at codon 388 of fibroblast growth factor receptor-4 (FGFR4) gene was evaluated… Expand
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